Inyathelo elinye elisondele kunyango olutsha lweCystic Fibrosis

I-Entrinsic Bioscience kunye nelayisensi yayo i-Nuvara Therapeutics ibhengeze ukuba inyathelo elinye elikufutshane ekusebenziseni iifomyula ze-RxAA njengonyango lwezigulana ezine-Cystic Fibrosis Class Class mutations. Umphandi weYunivesithi yaseFlorida uGqr. Sadasivan Vidyasagar, umseki kunye nosihlalo webhodi yeengcebiso zesayensi yenkampani, kutshanje wabelane ngenye indlela yokubuyisela i-airway secretion ye-anion kwi-Experimental Biology 2022 inkomfa eyayibanjelwe e-Philadelphia.      

UVidyasagar kunye neqela lakhe, elibandakanya abaphandi abavela kwi-UF kunye ne-Entrinsic Bioscience, babonise ukuba ifomula ye-Nuvara ye-VS-009 inokuba luncedo kwizigulana ezine-Cystic Fibrosis Class Class mutations kunye neClass II kunye ne-III. Unyango lunokusetyenziswa lodwa okanye ludityaniswe nolunye unyango ukuphucula ukukhuselwa kwekloridi.

UStephen J. Gatto, uSihlalo oLawulayo weNuvara Therapeutics, uvuyisene no-Astrid Grosche kunye neqela lonke likaDkt Vidyasagar ngokuqhubeka nokuzibophelela ekuqhubeni iindlela ezintsha zokuvavanya umsebenzi we-epithelial wokuphefumula.

"Ndifuna ukubulela u-Astrid, uDkt. Vidyasagar kunye neqela lakhe lonke ngokuzibophezela kwabo ngokungakhathali ukusombulula iinguqulelo zeKlasi I kwiCystic Fibrosis, inguqu enokuchaphazela ukuya kuthi ga kwi-18% yabantu beCF," utshilo uStephen J. Gatto.

"Ezi zicatshulwa zimbini zibonisa ukuba i-ion-channel manipulation inokwenzeka kwi-epithelium yokuphefumula usebenzisa iifomyula ezichanekileyo ze-amino acids," waqhubeka uGatto. "I-ion-channel dysfunction ingundoqo kwizifo ezininzi, ezifana ne-CF kunye nezifo apho kukho ukwanda kwemveliso ye-mucous, kuquka i-asthma kunye ne-COPD. Ezi ndlela / unyango luya kusivumela ukuba silungelelanise ukungena kwee-ion kunye namanzi kumoya womoya kwinqanaba leselula kunye nemiphumo emibi encinci.

“Kusekho umsebenzi ekufuneka wenziwe, kodwa eli thuba linika umdla ngokwenene kwaye linokumela impumelelo kulawulo lwe-channelopathies kunye nezifo ezinxulumene noko,” utshilo uGatto.

UVidyasagar ukwabonise ipowusta kwisixhobo elebhu yakhe ephuhliselwe ukulinganisa ngcono i-peristalsis yamathumbu kunye nokunxibelelana koxinzelelo lwe-intraluminal, ukufinyela kwemisipha, kunye notshintsho kumthamo wolwelo.

"Ezi zicatshulwa zimbini ziyingqayizivele kuba zibonisa ukukwazi ukumodareyitha i-epithelial transmembrane proteins (eTMPs) kunye nokwakheka okukhethiweyo kwe-amino SAA (RxAAs)," kusho uDkt. William Denman, uMcebisi oyiNtloko wezoNyango kwiNuvara Therapeutics. "Oku kuvula umnyango wonyango olusebenzayo, olungeyotyhefu kwinqanaba leselula, nokuba yeyiphi na i-etiology."

UGqr. Denman uqhubeke wathi, “Unyango lwexesha elizayo ngoku lunokumiselwa kwaye lulungiselelwe ijelo ngalinye kunye nesifo – iyeza lokwenyani lomntu. Umsebenzi omninzi uyafuneka, kodwa oku kunokuvumela ezinye iindlela zonyango kwinqanaba leeselula kuzo zonke izifo ezineziphumo ebezingalindelekanga ezincinci.

I-Entrinsic Bioscience sisiqalo se-UF esikwi-UF Innovate | Ukukhawulezisa eSid Martin Biotech eAlachua. Inkampani iphuhlisa yonke into-yendalo, i-glucose-free formulations ye-hydration yeklinikhi, impilo yamathumbu kunye nempilo, i-allergies, kunye nokunakekelwa kwesikhumba.