Nangona ikakhulu isisifo sokuphefumla, i-COVID-19 ibonakaliswe ibangela uluhlu lweempendulo, kubandakanya neziphumo ezibi kwinkqubo yentliziyo. Ezinye izigulana zibonise impendulo evuthayo enokuthi iqalise i-thrombosis, kwaye kukho izehlo eziphezulu kulabo banesifo esibi.
Kwiphepha lokuqala, abaphandi kwiDyunivesithi yasePennsylvania bachonge abalamli abaphambili bokudumba kunye nesifo sentliziyo kwizigulana ze-COVID-19 ezinxibelelene kakuhle nokusebenza kweplatelet kwinkqubo yeBioFlux. Iqela liphinde labonisa ukuba i-Syk inhibitor fostamatinib iguqule i-platelet hyperactivity kwiimvavanyo ze-BioFlux. Abaphandi bagqibe ekubeni oku kubonisa indlela eyahlukileyo, ejoliswe kuyo yokubonisa ukulungelelanisa esi siphumo.
Kwiphepha lesibini, abaphandi beYunivesithi yaseTuebingen babonise ukuba ukunciphisa i-cAMP (i-cyclic adenosine monophosphate) amanqanaba kwiiplatelet kwandisa i-antibody-induced platelet coagulation kunye nokwakheka kwe-thrombus. Ezi ziphumo zithintelwe yi-Iloprost, i-arhente yonyango evunyiweyo yeklinikhi eyandisa amanqanaba e-intracellular cAMP kwiiplatelet.
Omabini amaphepha axhomekeke kwinkqubo ye-BioFlux ukuvavanya ukusebenza kweplatelet kwizigulana ze-COVID-19. Inkqubo ye-BioFlux isebenza "njenge-artery kwi-chip" elawula ngokuchanekileyo i-cell-environment ukuze ilinganise iimeko emzimbeni womntu, ibonelela ngeqonga elifanelekileyo lomsebenzi wegazi elinxulumene ne-COVID-19. Isetyenziswa kwiilebhu ezingaphezu kwama-500 kwihlabathi jikelele, inkqubo ye-BioFlux iyafumaneka kwiindlela ezahlukeneyo zokukhawulelana neemfuno zesicelo sayo nayiphi na ilabhoratri. Iinkqubo ziyafumaneka ezinoluhlu lwezakhono kunye neziphumo kwaye zisetyenziswa kuphando olusisiseko ngokufunyanwa kweziyobisi kunye nophuhliso loxilongo.
INTO ONOKUYITHATHA KWELI NQAKU:
- In the first paper, researchers at the University of Pennsylvania identified key mediators of inflammation and cardiovascular disease in COVID-19 patients that correlated positively with platelet activation in the BioFlux system.
- Used in more than 500 labs globally, the BioFlux system is available in a variety of configurations to meet the application requirements of any laboratory.
- In the second paper, University of Tuebingen researchers demonstrated that reduced cAMP (cyclic adenosine monophosphate) levels in platelets increased antibody-induced platelet coagulation and thrombus formation.
