UKUQALA
Usulelo oluphezulu lwe-SARS-CoV-2 lwenzeka e-Chile ngaphandle kwephulo lokugonya elingqongqo, elixhomekeke ikakhulu kugonyo lwentsholongwane olungasebenziyo oluvela kwi-Sinovac Biotech kwaye ukusa kwinqanaba elingaphantsi kugonyo lwe-mRNA olusuka kwi-Pfizer/BioNTech kunye nogonyo lwentsholongwane olungaphindi luphindaphindeyo oluvela. Oxford/AstraZeneca kunye neCansino Biologicals.
Utyando lokugqibela oluxeliweyo elizweni lulawulwa ziintlobo ezahlukeneyo ze-SARS-CoV-2 iGamma kunye neLambda, leyo yangaphambili yachazwa njengokwahluka kwenkxalabo kwiinyanga ezininzi ezidlulileyo kwaye le yokugqibela isandula ukuvunywa njengomahluko womdla yi-WHO. Ngelixa ukwahluka kweGamma kunotshintsho oluli-11 kwiprotein ye-spike ebandakanya ezo zikwindawo ye-receptor-binding (RBD) eyayanyaniswa nokwanda kokubophelela kwe-ACE2 kunye nosulelo (N501Y) okanye ukubaleka komzimba (K417T kunye ne-E484K) iprotein ye-spike yokwahluka kweLambda inomohluko owodwa. iphethini yokuguqulwa kwe-7 (Δ246-252, G75V, T76I, L452Q, F490S, D614G, T859N) apho i-L452Q ifana nokuguqulwa kwe-L452R echazwe kwi-Delta kunye ne-Epsilon.
Utshintsho lwe-L452R lubonakaliswe ukunika ukubaleka komzimba kwi-monoclonal antibodies (mAbs) kunye ne-plasma yokubuyisela.
Ngaphezu koko, ukuguqulwa kwe-L452R kuye kwaboniswa ukwandisa ukusuleleka kwentsholongwane kwaye idatha yethu ibonisa ukuba ukuguqulwa kwe-L452Q ekhoyo kwi-Lambda eyahlukileyo inokunika iipropati ezifanayo kwezo zichazwe kwi-L452R. Okubangela umdla kukuba, ukucinywa kwe-246-252 kwindawo ye-N-terminal (NTD) ye-Lambda Spike ibekwe kwindawo ye-antigenic supersite kwaye ke, oku kucinywa kunokuba negalelo ekubalekeni komzimba. Ngaphaya koko, uguqulo lweF490S lukwanxulunyaniswa nokubalekela kwisera ye-convalescent.
Ngokuhambelana nezi zandulelayo, iziphumo zethu zibonisa ukuba iprotein ye-spike yokwahluka kweLambda inika ukubaleka komzimba kwii-antibodies ezibangwa lugonyo lweCoronaVac. Nokuba ukwahluka kweLambda nako kuqhwesha kwimpendulo yeselula eboniswe ukuba yenziwe yiCoronaVac akwaziwa.
Sikwaqaphele ukuba iprotein ye-spike yokwahluka kweLambda ibonise ukosuleleka okonyukayo xa kuthelekiswa neprotein ye-spike yokwahluka kwe-Alpha kunye ne-Gamma, zombini zinengxelo eyongeziweyo yokosulela kunye nokusulela.
Ngokudibeneyo, idatha yethu ibonisa okokuqala ukuba utshintsho olukhoyo kwiprotein ye-spike yokwahluka kweLambda kunikezela ukubaleka kwii-antibodies eziphazamisayo kunye nokwanda kosulelo. Ubungqina obuthiwe thaca apha bomeleza uluvo lokuba amaphulo amakhulu okugonya kumazwe anezinga eliphezulu lokujikeleza kwe-SARS-CoV-2 kufuneka akhatshwe luphononongo olungqongqo lwe-genomic olujolise ekuchongeni ngokukhawuleza iindawo ezizimeleyo zentsholongwane ezithwele uguquko lwe-spike kunye nezifundo ezijolise ekuhlalutyeni impembelelo yezi. utshintsho ekuphunyukeni komzimba kunye nokuphumelela kogonyo.
I-COVID-19 ihamba ngokukhawuleza. Oku kunokubonwa eHawaii apho amanani ayephantsi kwaye atsibela ukurekhoda phezulu kunye nokhenketho olukhulayo.
