I-Helio Health, inkampani yokhathalelo lwempilo eqhutywa yi-AI egxile ekurhwebeni iimvavanyo zokubona umhlaza kwangethuba kwigazi elilula, namhlanje ibhengeze ukuba unxibelelwano lwe-Hepatology lupapashe iziphumo ezilungileyo ezivela kuphononongo lwe-ENCORE oluqinisekisa ukusebenza okuqinileyo kwekliniki ye-HelioLiver ekuboneni ubukho be-hepatocellular carcinoma (HCC) , uhlobo oluqhelekileyo lwesifo somhlaza wesibindi kunye nomhlaza wesixhenxe oqhelekileyo emhlabeni wonke kodwa okwesibini ekufeni okunxulumene nomhlaza, ngokuphindaphindiweyo ngenxa yokuxilongwa kwexesha elide.1 Kulo mzekelo, umfama, uphando lweSigaba se-2 se-91, uHelioLiver ubonise ukuchaneka okuphezulu (76) %) kunye novelwano oluphezulu (57%) ekufumaneni inqanaba lokuqala (inqanaba I kunye ne-II) i-HCC, ngokugqithiseleyo ukugqwesa ezinye izixhobo ezifumaneka kwikliniki ezifana ne-AFP (65%), i-GALAD (47%), kunye ne-ultrasound (2,3%). I-85 Xa uqwalasela i-HCC iyonke, i-HelioLiver yenze kwi-91% ye-sensitivity kunye ne-2% efanayo.XNUMX
| Iimvavanyo zokuxilonga ze-HCC | Inqanaba lokuqala (I + II) Uvakalelo | Ubuntununtunu bebonke |
| HelioLiver2 | 76% | 85% |
| AFP (≥ 20 ng/mL)2 | 57% | 62% |
| Inqaku le-GALAD (≥ -0.63)2 | 65% | 75% |
| omoya3 | 47% | 84% |
| Qaphela: Itheyibhile ibonisa uvakalelo lwe-HelioLiver kwi-91% ethile2 | ||
| 2 ULin N, kunye nabanye. 2021. | ||
| 3 UTzartzeva K, et al. 2018. |
I-Helio yavelisa iqonga layo lokulandelelana kwesizukulwana esilandelayo, i-ECLIPSETM, ukuchonga iithagethi ze-77 ze-methylation kwii-genes ze-28. Ezi mpawu ze-DNA zisebenza ngokudibanisa ne-serum HCC iiprotheyini ze-AFP, i-AFP-L3%, kunye ne-DCP yokuphucula i-algorithm ye-multi-analyte.
• Indawo ephantsi kophawu lokusebenza (i-AUROC) ye-HelioLiver yayiyi-0.944, ibonisa isakhono esingcono kakhulu sokuxela kwangaphambili kunezinye iimvavanyo.
• Kwi-fixed specificity ye-87.5%, i-HelioLiver ifumene i-87% yobuntununtunu kwi-HCC yasekuqaleni kunye ne-90% yobuntununtunu jikelele.
• I-10 ye-28 yezakhi zofuzo ezisetyenziswe kuvavanyo lwe-HelioLiver zifunyenwe zibandakanyeka ngokuthe ngqo kwiindlela ze-molecular ezaziwa ukuba zibandakanyeke kwi-HCC pathogenesis ngelixa enye kuphela ye-497 ephandwayo kodwa engakhethwanga i-gene ye-XNUMX idibene neendlela ezifanayo, ebonisa ukuba abamakishi kwi-HelioLiver bangaphezulu. ngokwebhayoloji ibalulekile kunovavanyo olusebenzisa ezi zezinye iijini.
I-Hepatology Communications yijenali esemthethweni yokufikelela kwi-open, i-peer-reviewed ye-American Association for the Study of Liver Diseases (AASLD), ezinikele ekuhanjisweni ngokukhawuleza kophando oluphezulu kwi-hepatology. I-AASLD ngowona mbutho uhlonitshwayo wemigaqo yezonyango kwizifo zesibindi eUnited States.
I-HelioLiver iphantsi kovavanyo olongezelelweyo njengenxalenye ye-Helio's pivotal, i-biomarker study prospective, i-CLiMB (NCT03694600), apho ukusebenza kovavanyo kuya kufaniswa ngokuthe ngqo ne-ultrasound usebenzisa i-MRI ye-multi-phasic njengomgangatho wokunyamekela ukuxilongwa kwe-HCC.
