Uvavanyo loLuntu ngoku luQalisa uThintelo lokugonya kwi-Parkinson's Disease

Kwezi zitofu ezine, iziphumo ezingcono zafunyanwa nge-PV-1950, ejolise ngaxeshanye i-epitopes ezintathu ze-B cell zale molekyuli ye-pathological, ebonisa ukuncitshiswa okubalulekileyo kwe-α-Synuclein kunye ne-neurodegeneration kwiingqondo zokugonywa kwe-hα-Syn D iigundane zomgca.            

UGqr. Agadjanyan uthe, “Uphuhliso lwesitofu sokugonya esikhuselekileyo nesamajoni omzimba esijolise kuzo zonke iintlobo ze-pathological α-Synuclein yinjongo ye-IMM. Okubalulekileyo, isitofu sethu sokugonya esisebenzayo, i-PV-1950, ivelise imveliso eyomeleleyo ye-antibody, ukunciphisa i-pathological α-Synuclein kunye nokuphucula ukusilela kweemoto kwimodeli yempuku yesifo ilungele ukuvavanywa kulingo lothintelo lwezonyango”. Waqhubeka wathi, "I-PV-1950 ineenguqulelo ezimbini - enye isekelwe kwi-DNA kunye nenye kwiprotheyini ephinda iphinde ibuyele. Ugonyo olongezelelweyo olune-heterologous DNA kunye nogonyo lweprotheyini yenye indlela ethembisayo yokufumana iimpendulo ezinkulu ze-antibody. "

I-PD sisifo sesibini esixhaphakileyo se-neurodeergenerative yokuguga esichaphazela zombini iimoto kunye nokusebenza kwengqondo. Iziko lijonge kunyango lothintelo olusekwe kugonyo lwezifo ze-neurodeergenerative ezifana nePD, DLB, kunye ne-AD. Isitofu sokugonya se-immunogenic sinokuba yeyona ndlela isebenzayo yokuthintela / ukuthintela ukudityaniswa kweprotheyini enetyhefu ye-α-Synuclein ekuqokeleleni nasekusasazekeni kwengqondo kunye nokumisa okanye ukulibazisa isifo, utshilo i-IMM.

“I-α-Synuclein yiprotheni ye-neuronal edityaniswa ngokwemfuza kunye ne-neuropathologically kwii-α-synucleopathies ezahlukeneyo, kubandakanywa nesifo sika-Parkinson (PD). Nje ukuba i-pathology iqale, kuba nzima ukuyiyeka, ngoko ke ukusebenzisa isitofu sokugonya esisekwe kwinqanaba le-MultiTEP esivela kwi-IMM Nuravax sifuna ukumisa okanye ukulibazisa isifo kubantu abasengozini ye-α-synucleopathies, utshilo u-Roman Kniazev.