Isitofu esitsha soThintelo se-Alzheimer's Sifumana iSibonelelo

I-Institute for Molecular Medicine (IMM), umbutho ongenzi nzuzo ozinikele kuphando olusisiseko kunye noguqulelo lwemolekyuli ukuphuhlisa izitofu ezikhuselekileyo, ezisebenzayo ezichasene nesifo se-Alzheimer kunye nezinye izifo ze-neurodeergenerative, namhlanje ibhengeze ukuba inikwe isibonelelo sezigidi ezili-12 zeedola kwiZiko leSizwe Ukuguga (NIA) icandelo le-US National Institutes of Health (NIH) ukuxhasa iimvavanyo zeklinikhi ze-beta-amyloid (Aβ) izitofu ezisekelwe kwi-DNA (AV-1959D) kunye neprotheyini ephinda iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphindwe kwakhona (AV-1959R) yokuthintela isifo se-Alzheimer's. (AD). Ngokusebenzisana neYunivesithi yaseCalifornia, u-Irvine (uPhando oPhambili, uDavid Sultzer, MD) kunye neYunivesithi yaseSouth California (uPhando oPhambili, uLon Schneider, MD), i-IMM (uMphandi oyiNtloko kunye noqhagamshelwano lwe-NIH, uMichael Agadjanyan, Ph.D.) ulindele ukuqalisa isifundo seklinikhi seSigaba soku-1 e-US kwikota yesibini ka-2022.            

Ukuza kuthi ga ngoku, unyango lwe-AD lugxile kakhulu ekunyangeni i-pathology esisiseko emva kokuba isifo sibambile. Nangona kunjalo, xa i-pathology iqala kwaye i-neuron yonakalisiwe, kuba nzima ukunqanda isifo. Idatha yangoku icebisa ukuba isitofu sokugonya esifakwe phambi kokuba isifo siqale sinokuyinqanda indibaniselwano ye-Aβ kwaye ilibazise i-AD.

"I-Aβ inendima ephambili kwinkqubo apho i-AD ikhula," kusho uDkt Agadjanyan, iSekela likaMongameli we-IMM kunye neNtloko yeSebe le-Immunology. “Idatha yethu epapashiweyo yangaphambi kweklinikhi, kunye neziphumo zonyango ezifunyenwe nge-monoclonal anti-Aβ antibodies, zibonisa ukuba unyango lothintelo kuphela olunokulibazisa okanye luyimise i-AD. Ngenxa yesidingo solawulo lwenyanga lwengxiliniso eziphezulu kakhulu ze-monoclonal anti-Aβ antibodies, akukho ngqiqweni ukuzisebenzisa kunyango lothintelo lwabantu abasempilweni abasemngciphekweni we-AD. Ngokwahlukileyo koko, irejimeni yethu yokuthintela, equlathe i-AV-1959D njengesitofu sokugonya esiphambili kunye ne-AV-1959R njengesitofu sokugonya, inokubangela amanqanaba aphezulu e-antibodies ezithintela ukudityaniswa kwe-Aβ kunye nokulibazisa ukuqala kwesifo kubantu abangenangqondo abasengozini ye-AD. ”

Uphononongo olupapashiweyo kuzo zombini izitofu zokugonya i-AV-1959D kunye ne-AV-1959R zibonise ukuba zikhuselekile kwaye zine-immunogenic kwiimpuku, imivundla kunye neeprimates ezingezozabantu. Ezi zitofu zisekelwe kwi-immunogenic egqithisileyo kunye neteknoloji yeqonga ye-MultiTEP yehlabathi enikwe ilayisenisi ngokukodwa kwi-Nuravax, eya kongamela urhwebo, uphuhliso kunye nezivumelwano zemvumelwano kunye neenkampani ze-biopharmaceutical.