I-Gingko biloba inciphisa umonakalo wentliziyo

Ukusebenza okuqhelekileyo komzimba womntu kufuna ukuhamba ngokukhawuleza kwamandla ngendlela ye-adenosine triphosphate (ATP). Umjikelezo we-tricarboxylic acid (TCA), inkqubo ebalulekileyo yokuvelisa i-ATP kwi-mitochondria, i-hub enkulu ye-metabolites kwaye iqinisekisa ukulingana okuhle phakathi kwe-cyclic intermediates, ebizwa ngokuba 'yi-metabolic flux.' Le ntsholongwane ikholelwa ukuba iphazamisekile kwiingxaki ezinxulumene nentliziyo njenge-myocardial ischemia (MI), apho ukuhamba kwegazi ukuya entliziyweni kuyancipha, imisipha yentliziyo, okanye i-cardiomyocytes, ekufumaneni ioksijini eyaneleyo. Ukunciphisa i-ATP synthesis kunye nokunyuka kwe-glucose breakdown, okanye "glycolysis," phawula i-MI, kodwa ukuxhaphaza umjikelo we-TCA kwizicwangciso zonyango kunzima.       

I-Ginkgo biloba L. isicatshulwa (i-GBE), equlethe i-bilobalide esebenzayo, isetyenziswe ngokuqhelekileyo njengeyeza eliqhelekileyo lokunyanga izifo zentliziyo ye-ischemic, kodwa indlela yokusebenza kwayo ayaziwa. Izazinzulu ezikhokelwa nguProf. Jinlan Zhang ovela kwiZiko laseTshayina leMateria Medica zatyhila ngempumelelo isayensi emva kweziphumo ze-GBE ze-cardioprotective kwisifundo esitsha. "Ulawulo lwe-GBE lwe-metabolism yamandla yatsala ingqalelo yethu kuba intliziyo isebenza ngokuqhubekayo kwaye idinga amandla ukunika amandla inkqubo yokujikeleza," utsho uProf. Zhang.

Uphononongo, olwapapashwa kwi-Journal of Pharmaceutical Analysis, lubonisa indlela ukuhanjiswa kwekhabhoni ukusuka kwi-glycolysis ukuya kumjikelezo we-TCA kuvaliwe kwi-cardiomyocytes echaphazelekayo ye-MI. Oososayensi bafumanisa ukuba i-TCA flux yaphazamiseka ngokucacileyo kula maseli, akhetha ukusebenzisa enye imithombo yekhabhoni kunokuba i-glucose ibonelele ngokuqhubekayo amandla. Nangona kunjalo, ukuvinjelwa kunye nokuphazamiseka kwemveliso ye-ATP ayinakuthintelwa kwiiseli ezilimele. I-Ischemic cardiomyocytes iqulethe ubuninzi bee-enzymes eziguqule imithombo yekhabhoni kwi-metabolites, kokubili ngaphambi nangexesha lokujikeleza kwe-TCA, enokuthi ibangele ukuba i-metabolites iqokelele kwaye iphazamise i-metabolism flux, ekubeni ingenako ukungena kumjikelezo ngokugqithisileyo.

Okubangela umdla kukuba, ekuphatheni iiseli ezonzakeleyo nge-GBE, ababhali bafumanisa ukuba i-bilobalide inokukhusela i-mitochondria kwaye igcine isizukulwana se-ATP. Amanqanaba e-enzyme kwiiseli eziphathwayo ehla kwaye anqanda ukuqokelelwa kwe-metabolite, ukuphuculwa kwe-metabolic flux, kunye nokunciphisa uxinzelelo kwiiseli zentliziyo. Oku kuguqulwa kwe-metabolic flux kwiiseli eziphathwe nge-GBE zahlukile kwiindlela ezichazwe ngaphambili.

Baye bavavanya izicubu ze-myocardial zeempuku eziphathwe nge-GBE, ezibonise iimpawu zomonakalo ongaphantsi we-MI kuneisampulu zezicubu ezinganyangekanga. Iziphumo zazihambelana nezo ze-ISO-enzakeleyo iiseli, ebonisa ukuba i-bilobalide ikhusela imisipha yentliziyo.

Nangona uphando lweziyobisi lwe-metabolic kwi-MI lusanda kufumana ukuthamba, impumelelo isekude kakhulu. Iziphumo zonyango lwe-bilobalide ezifunyenwe kolu phononongo aziboneleli kuphela ngobungqina obuninzi be-MI's metabolic pathology, kodwa zikwanika inkuthazo kunyango olutsha lwamayeza.

"I-MI iyingozi enkulu kwimpilo yabantu emhlabeni jikelele kwaye icacise i-pathophysiology yayo kunye nonyango olunokubakho luyimfuneko," kusho uProf. Zhang. "Iziphumo zethu zibonakala zithembisa, kwaye silindele ukufumana inkuthazo kolu phando kwindlela ye-metabolic kunye nesiseko sezinto kunyango lwe-MI," uqukumbela ngelitshoyo.