"Injongo kukuphuhlisa unyango lokuphucula umsebenzi we-G3PP kubantu ukunciphisa ifuthe elinobuthi lweswekile kunye nokujongana nesizathu sezifo ezinxulumene nokuguga ezinxulumene noshukela ogqithiseleyo kunye nokutya okunamafutha," kusho uDkt. Marc Prentki, iNzululwazi yeNzululwazi kwiYunivesithi yaseYunivesithi. Iziko loPhando lweSibhedlele saseMontreal kunye noMlawuli weZiko loPhando lweSishukela saseMontreal, okhokela uphando kunye noDkt. SR Murthy Madiraju.
I-activators ye-G3PP njengamachiza okunyanga izifo ze-cardiometabolic kunye nokukhuthaza ukuguga okunempilo ziphuhliswa yi-Montreal biotech, i-NIMIUM Therapeutics, ekhokelwa yi-CEO uDkt Philippe Walker. U-Prentki usebenza njenge-CSO.
Iingcali zenzululwazi zisebenzise imodeli ye-C. elegans worm, eqhelekileyo kuphando ngokuguga, ukubonisa ukuba ukwanda komsebenzi we-G3PP kwandisa ixesha lokuphila kwaye kuphucula kakhulu impilo yezilwanyana. Umsebenzi ophakamileyo we-G3PP unciphise ukugcinwa kwamafutha kunye nokukhuselwa kwi-glucose engaphezulu kunye nemiphumo eyingozi yoxinzelelo lwe-oxidative. I-G3PP isebenza ngokuguqula i-glucose engaphezulu kwi-glycerol, enokuthi ikhutshwe ngokulula ngumzimba. I-G3PP nayo yaboniswa ukukhusela iiseli ze-beta ezikhupha i-insulin, eziphulukana nokusebenza xa i-glucose eninzi ikhona.
Olu phando luxhaswe yinkxaso-mali evela kwiCanada Institutes of Health Research. Iqela laliquka u-Elite Possik, umbhali wokuqala wenqaku, uClémence Schmitt, u-Anfal Al-Mass, u-Ying Bai, uLaurence Côté, uJohanne Morin, uHeidi Erb, uAbel Oppong, uWahab Kahloan, J. Alex Parker, SR Murthy Madiraju, noMarc Prentki.
INTO ONOKUYITHATHA KWELI NQAKU:
- “The goal is to develop therapies to enhance G3PP function in humans to reduce the toxic effects of sugar and address the cause of aging-related diseases associated with excessive sugar and fat intake,”.
- Marc Prentki, Principal Scientist at the University of Montreal Hospital Research Centre and Director of the Montreal Diabetes Research Center, who leads the research with Dr.
- elegans worm model, common in research on aging, to demonstrate that increasing G3PP activity prolongs lifespan and significantly improves healthspan of the animals.
