Isigaba esitsha soku-1 sovavanyo lwezonyango lwabantwana be-CNS Tumors

I-EpicentRx, Inc., inqanaba lezonyango kunye nenkampani yesixhobo, ngokubambisana neZiko loMhlaza waBantwana laseTexas eHouston, namhlanje libhengeze ukuqala kweSigaba soku-1 sophononongo lokuhlola ukhuseleko kunye nenzuzo yemolekyuli encinci ekhokelayo, iRRx-001, kunye. i-irinotecan kunye ne-temozolomide kwizigulana zabantwana abane-recurrent or progressive malignant solid and central nervous system tumors. Uphononongo, i-PIRATE (NCT04525014) yakhawulwa kwaye yaphuhliswa ngoogqirha uHolly Lindsay kunye noPatricia Baxter kwiZiko leCancer laBantwana laseTexas kwaye baya kubhalisa izigulane ezi-1 ukuya kwi-21 yeminyaka ubudala kunye ne-recurrent or progressive-malignant primary brain or progressive primary embi okanye i-spinal cord tumors kunye ne-tumor eqinile, ngaphandle kokuba iilymphoma.        

I-genesis yolingo lwe-PIRATE yayisekwe kulingo lwezonyango olwandulelayo oluseke ubungqina obunokubakho bokuba i-RRx-001 yonyusa unikezelo lwechemotherapy kunye nokuthathwa kwamathumba. ISigaba soku-1 solingo lwezonyango olubizwa ngokuba yi-G-FORCE (NCT02871843) kunye neSigaba se-1/2 solingo lwezonyango olubizwa ngokuba yi-BRAINSTORM (NCT02215512) lubonise ukhuseleko lwe-RRx-001 kunye nobungqina obunokubakho boncedo lweklinikhi kwizigulane zabantu abadala abane-glioblastoma okanye i-GBM kunye nengqondo. metastases, ngokulandelanayo.

Iiseli zomhlaza zicwangciselwe ukuhamba kwiithishu ezahlukeneyo emzimbeni, apho zibeka umqobo wokuthintela ukuhanjiswa kweziyobisi. Enye yeengcamango zolu vavanyo kukuba i-RRx-001 "inokuthi "iqheleke" i-tumor microenvironment, okwenza i-tumor vasculature isebenze ngakumbi ekuhanjisweni kwe-irinotecan kunye ne-temozolomide ukwenzela ukuba ukuphumelela kwabo kwandiswe ngelixa ukugqithisa iiseli ze-immune njenge-macrophages ukuya ekuhlaselweni. ngokuchasa kwayo uphawu lwe-CD47 oluthi “ungandityi”. Enye i-hypothesis kukuba i-RRx-001 iya kukhusela izicubu eziqhelekileyo, kodwa kungekhona i-tumor, kwi-toxicity ye-irinotecan kunye ne-temozolomide.

"Siyavuya ukuqalisa olu pho nonongo kunye ne-RRx-001 kunye nokuseka indima yayo njengonyango olunokubakho kwi-tumor ye-CNS yabantwana," watsho uTony R. Reid, MD, Ph.D., iGosa eliLawulayo eliyiNtloko le-EpicentRx. “Olu lingo belungazukwenzeka ngaphandle kwenkxaso emandla yeZiko loMhlaza waBantwana laseTexas. Njengoko ulingo lwezonyango kumathumba e-CNS yabantu abadala lucebisa ukuba i-RRx-001 inokubonelela ngenzuzo kubantwana babantwana, ukusebenzisana kwethu nabo bubungqina bokuzinikela kwale nkampani ukulandela idatha naphi na apho ikhokelela khona.

"Kukho ukunyanzeliswa kwangaphambili kunye nengqiqo yeklinikhi yokhuseleko kunye nokusebenza okunokwenzeka kwe-RRx-001 kwi-CNS tumors," watsho uDkt Holly Lindsay, MD, uNjingalwazi oNcedisayo, iSebe le-Pediatrics, iCandelo le-Hematology-Oncology, i-Baylor College of Medicine kunye nokukhokela. Umphandi. "Izehlo ze-CNS tumors kubantwana kunzima kakhulu ukunyanga, kwaye silindele ukuba isifundo se-PIRATE siza kuvelisa idatha ebalulekileyo ukunceda ukwazisa izigqibo zonyango kwixesha elizayo."