I-amygdala-isakhiwo sobuchopho esandiswa kubantwana abaneminyaka emibini ubudala abafunyanwe ukuba bane-autism spectrum disorder (ASD)-iqala ukukhula ngokukhawuleza phakathi kwe-6 kunye ne-12 yeenyanga ubudala, iphakamisa uphando oluxhaswa ngemali yiNational Institutes of Health. I-amygdala ibandakanyeka ekuqhubeni iimvakalelo, njengokutolika inkangeleko yobuso okanye ukuziva usoyika xa ujongene nesoyikiso. Iziphumo zibonisa ukuba unyango lokunciphisa iimpawu zoluphazamiseko lunokuba nethuba elikhulu lokuphumelela ukuba luqala kunyaka wokuqala wobomi, phambi kokuba i-amygdala iqale ukukhula ngokukhawuleza.
Olu phononongo lubandakanya iintsana ezingama-408, ezingama-270 kubo babesengozini enkulu yokuba noluphazamiseko ngenxa yokuba benabantwana bakowenu omdala onoluphazamiseko, 109 abasakhula abantwana, kunye neintsana ezingama-29 ezineFragile X syndrome, uhlobo oluzuzwe njengelifa lophuhliso nengqondo yokhubazeko. Abaphandi baqhube i-MRI scans zabantwana kwi-6, i-12 kunye ne-24 yeenyanga ubudala. Bafumanisa ukuba iintsana ezingama-58 eziye zaphuhlisa i-ASD zine-amygdala eqhelekileyo kwiinyanga ze-6, kodwa i-amygdala eyandisiweyo kwiinyanga ezili-12 kunye neenyanga ze-24. Ngaphezu koko, ngokukhawuleza izinga lokukhula kwe-amygdala, ubukhulu beempawu ze-ASD kwiinyanga ezingama-24. Iintsana ezine-Fragile X syndrome zinendlela eyahlukileyo yokukhula kwengqondo. Babengenazo iiyantlukwano ekukhuleni kwe-amygdala kodwa ukwandiswa kwesinye isakhiwo sobuchopho, i-caudate, eyayidityaniswe nokunyuka kokuziphatha okuphindaphindiweyo.
Iqela lophando, inxalenye ye-NIH Autism Centres of Excellence Infant Brain Imaging Study network, yayikhokelwa nguMark Shen, Ph.D., weYunivesithi yaseNorth Carolina e-Chapel Hill kunye ne-Infant Brain Imaging Study. Uphononongo luvela kwi-American Journal of Psychiatry. Inkxaso-mali yanikezelwa yi-NIH ka-Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute of Environmental Health Sciences kunye neNational Institute of Mental Health.
Ababhali bacebise ukuba ubunzima bokucubungula ulwazi lwe-sensory ngexesha lobusana kunokugxininisa i-amygdala, ekhokelela ekukhuleni kwayo.
Uluphazamiseko luchaphazela indlela umntu aziphethe ngayo, anxibelelana ngayo nabanye, anxibelelane kwaye afunde ngayo.
INTO ONOKUYITHATHA KWELI NQAKU:
- The findings indicate that therapies to reduce the symptoms of ASD might have the greatest chance of success if they begin in the first year of life, before the amygdala begins its accelerated growth.
- They found that the 58 infants who went on to develop ASD had a normal-sized amygdala at 6 months, but an enlarged amygdala at 12 months and 24 months.
- The study included 408 infants, 270 of whom were at higher likelihood of ASD because they had an older sibling with ASD, 109 typically developing infants, and 29 infants with Fragile X syndrome, an inherited form of developmental and intellectual disability.
