Ayisiyo kugonyo kuphela kodwa kunyangwa amayeza okunyanga i-COVID-19. Le ngxelo isekwe kuphando olupapashwe eYurophu kwaye ibonelelwe iguqulelwe kwaye ayilungiswanga ngenjongo yolwazi.
Ingxelo yenzelwe imboni ye-pharma, kodwa inika isishwankathelo esineenkcukacha ngakumbi apho kusukelwa khona unyango okanye ugonyo lumi eYurophu.
Nangona uphuhliso lwezitofu zokulwa nentsholongwane entsha ye-corona luqhubeka ngesantya esingazange sibonwe ngaphambili, akunakulindeleka ukuba babe sele befumanekile kugonyo oluninzi ngowama-2020.
Iiprojekthi eziqhubekayo zokunikezelwa kwakhona kwamachiza onyango
Ugxininiso ikakhulu kwiimveliso zonyango esele zivunyiwe sesinye isifo okanye ubuncinci kuphuhliso. Ukuzibuyisela endaweni yazo kunokuphumelela ngokukhawuleza kunophuhliso olutsha olusisiseko.
Inani leziyobisi esele zikhona ziyavavanywa ukuba azilunganga na isifo se-corona Covid-19. Bahlala belilinye lamaqela amathathu alandelayo:
- Amachiza antsholongwane ezazenzelwe i-HIV, i-Ebola, i-hepatitis C, umkhuhlane, i-SARS okanye i-MERS (zizifo ezibini ezibangelwa zezinye i-coronaviruses). Ziyilelwe ukuba zithintele ukuphindaphindeka kwentsholongwane okanye zithintele ukungena kwiiseli zemiphunga. Iyeza elidala lemalariya liyavavanywa, kwaye ukusebenza kwalo ngokuchasene neentsholongwane kusandula kufunyanwa kutshanje.
- Amagciwane omzimba Umz. B. ngokuchasene nesifo samathambo okanye isifo sokudumba esidunjelweyo. Zenzelwe ukuba zinciphise ukukhusela komzimba ukuze zingonakalisi ngaphezu kweentsholongwane ngokwazo.
- Amayeza ezigulana zemiphunga , umz. B. zaphuhliswa ngokuchasene ne-idiopathic pulmonary fibrosis. Zenzelwe ukukhusela imiphunga yesigulana ekubeni ikwazi ukubonelela ngegazi ngeoksijini eyaneleyo.
Nangona kunjalo, kusekho iiprojekthi zophuhliso lwamachiza amatsha.
Ukufumana ukucaca ngokukhawuleza malunga nokufaneleka kwamayeza
Kwizifundo ezininzi apho la mayeza ayekhona kwaye kuvavanywa ukulunga e-China nakwezinye iindawo, kuphela zizigulana ezimbalwa ezazibandakanyekile; kwaye akusoloko kuthelekiswa ngokuthe ngqo nezigulana ezifumana kuphela unyango olusisiseko ngaphandle kwamayeza ongezelelweyo. Ezi zifundo zinokumiselwa ngokukhawuleza, kodwa iziphumo zazo zihlala zingenangqondo. Kukwakho nezigulana ezininzi ze-Covid-19 eziklinikhi kwilizwe liphela, kodwa azikho kangako ukuba zinokusetyenziselwa ukuvavanya ngokupheleleyo onke amayeza acetywayo ngoku.
I-Arhente yamaYeza yaseYurophu (i-EMA) ke ibhenele kwiinkampani nakumaziko ophando ukuba baququzelele izifundo zamazwe ngamazwe, ezomkhosi oxhobileyo, ezilawulwayo nezingahleliwe kumayeza abo kangangoko:
- "Amazwe ngamazwe" kuthetha ukuba amaziko ezonyango kumazwe aliqela ayabandakanyeka.
- “Ukuxhobisa ngezixhobo” kunye “nokulawulwa” kuthetha ukuba izigulana zohlulwe ngokwamaqela athe umntu ngamnye wanikwa unyango olwahlukileyo: bonke bafumana unyango olusisiseko olufanayo, kodwa iqela ngalinye ngaphandle kwelinye lifumana iyeza elinye lokuvavanywa. Kwiqela lokugqibela (iqela lolawulo), nangona kunjalo, unyango olusisiseko lusahlala.
- "Ukungahleliwe" kuthetha ukuba abaguli abazimiseleyo babelwa ngokungacwangciswanga kwelinye lamaqela.
Ezo zifundo, ngokwe-EMA, ziya kuba nakho ukukhokelela kwiziphumo ezicacileyo ngokufaneleka kwamachiza xa kuthelekiswa nezifundo ezincinci, eziya kuthi ke zivumele iziyobisi ngokuchasene neCovid-19 ukuba zamkelwe.
Umbutho wezeMpilo weHlabathi (i-WHO) kutsha nje ubhengeze olo phononongo: olu phononongo, olubizwa ngokuba yi-SOLIDARITY, lujolise ekuthelekiseni iindlela zonyango ezine kunye neemveliso zonyango ezinokuthi zilungele utshintsho olusebenzayo kunye nolunye unyango olusisiseko. Olu phononongo ke ngoko luza kuba nezi "ngalo zophononongo" (= iintlobo zonyango) apho amawaka ezigulane kulindeleke ukuba athathe inxaxheba - esasazwa ngokungenamkhethe:
- Unyango olusisiseko kuphela
- Unyango olusisiseko + Remdesivir (inhibitor ye-RNA polymerase yentsholongwane)
- Unyango olusisiseko + i-ritonavir / lopinavir (ichiza le-HIV)
- Unyango olusisiseko + i-ritonavir / lopinavir (iyeza le-HIV) + beta interferon (amayeza e-MS)
- Unyango olusisiseko + i-chloroquine (iyeza lesifo seengcongconi)
Amaziko ezonyango avela eArgentina, eIran nase Mzantsi Afrika kufuneka athathe inxaxheba kolu phando. Ibhodi yokubeka iliso iya kuphononongwa rhoqo kwiziphumo zethutyana zophando kunye nokuphelisa iingalo zokufunda apho abaguli bengengcono (okanye babi kakhulu) kunakwicandelo lolawulo. Kuyenzeka ukuba kongezwe iingalo kolu phando, apho kuvavanywa khona ezinye iindlela zonyango.
Kwangelo xesha, uphononongo lokuFUMANEKA lwaqala eYurophu nase-UK ngolwakhiwo olufanayo, oluququzelelwa ngumbutho wophando wase-France i-INSERM. Izigulana ezingama-3,200 ezivela eJamani, eBelgium, eFrance, eLuxembourg, eNetherlands, eSpain, eSweden nase-UK kufuneka zithathe inxaxheba. Endaweni ye-chloroquine, kufuneka kusetyenziswe ichiza le-malaria i-hydroxychloroquine efanayo.
Amachiza antsholongwane
Isikhumbuzo ekuqaleni yaphuhliswa ngu KwiSayensi zeGiliyadi ngokuchasene nosulelo lwe-Ebola (ekungangqiniswanga), kodwa ibonakalisiwe iyasebenza ngokuchasene neentsholongwane ze-MERS elebhu. Iyeza elinezinto ezisebenzayo ngoku liyavavanywa kwizifundo ezininzi ngokuchasene ne-SARS-CoV-2.
ICytoDyn yiyo kuvavanya ukuba ngaba ichiza elichasayo ILeronlimab iyasebenza ngokuchasene coronavirus. Iphuhlisiwe ixesha elide ngokuchasene ne-HIV kunye nomhlaza webele ongena kathathu, esele ivavanyiwe kwizifundo. Ityala lesigaba II seCovid-19 ngoku lilindile.
UAbbVie unesinye isiyobisi se-HIV kunye Ukudibanisa zezithako ezisebenzayo lopinavir/ritonaviryenziwe yafumaneka kuvavanyo njengonyango lweCovid-19. Izifundo nezigulana ziyaqhubeka, kubandakanya nofundo apho izigulana nazo phefumla uNovaferon ku I-Beijing Genova Biotech . Le alpha interferon yamkelwe eTshayina kunyango lwe-hepatitis B. Iyeza ngoku liza kuvavanywa kwizifundo ezikhulu kwihlabathi liphela.
Inkampani yaseAscletis Pharma idibanisa izithethe endaweni yoko kwamkelwe e-China iziyobisi ze-hepatitis C kunye nesithako esisebenzayo UDanoprevir . Izifundo ziyaqhubeka.
E China, inkampani UZhejiang Hisun kwiyeza Izifundo zonyango lwezonyango kunyango lwe-Covid-19 ngesiyobisi esine-antiviral esinezixhobo ezisebenzayo ifavilavir yamkelwe. Ukuza kuthi ga ngoku, i-favilavir yamkelwe kuphela kunyango lomkhuhlane (eJapan nase China).
Kananjalo ngokuchasene nomkhuhlane kuphuhliso EA-002 , kinase inhibitor yenkampani Atriva Therapeutics eTübingen. Inkampani ngoku ivavanya ukuba ingaba isithako esisebenzayo nayo singanqanda ukwanda kwe-SARS-CoV-2.
I-APEIRON Biologics (Vienna) kunye neDyunivesithi yaseBritish Columbia bafuna uvavanyo lweziyobisi APN01 oluvele kuphando lweSARS kwaye sele luvavanyiwe kwizifundo zesigulana ngokuchasene nezinye izifo zemiphunga. Ibhloka imolekyuli kumphezulu weeseli zemiphunga ezisetyenziswa ziintsholongwane njengethagethi yokungena kwiiseli.
IChloroquine iye yaziwa njengesixhobo esisebenzayo kumayeza e-malaria, kodwa ibimiselwe kancinci kule minyaka idlulileyo. Nangona kunjalo, ngoku kuyaziwa ukuba isithako esisebenzayo sinokusetyenziswa nakwi-antivirally. Emva kovavanyo oluqinisekileyo lweelebhu malunga ne-SARS-CoV-2. Abaphandi baseTshayina okwangoku bafumana iindaba zokuba i-chloroquine ibonakalisile ukuba iyasebenza kufundisiso lweklinikhi. Inkampani yaseBayer emva koko yaqala kwakhona kwimveliso yamalungiselelo ayo oqobo kunye ne-chloroquine. Izifundo kwi
iziyobisi ze-malaria ezinesithako esisebenzayo ihydroxychloroquine ziyavavanywa ngoku. Inkampani i-Novartis ivumile ukuxhasa le mizamo kunye nokubonelela kwimeko yezigqibo ezilungileyo ngabasemagunyeni kulawulo ngasekupheleni kuka-Meyi ukuya kuthi ga kwi-130 yezigidi zeedosi zokwenza unyango lwabantu kwihlabathi liphela. Kwakhona, iSanofi ukubonelela ngesiyobisi se-malaria ngeli chiza likhoyo.
Ukusuka kwicandelo elidlulileyo lesicelo, ICamostat Mesilat ayisiyiyo i-arhente ye-antiviral-iyeza elamkelweyo eJapan ngokudumba kwepancreas. Nangona kunjalo, abaphandi abavela kumdibaniso wamaziko ophando waseJamani akhokelwa liZiko loBugebenga laseJamani eGöttingen bafumanise ukuba inqanda i-enzyme evela kwiiseli zemiphunga elebhu ebalulekileyo ekungeneni kwentsholongwane ye-SARS-CoV-2. Uceba ukuyivavanya kwizifundo zeklinikhi.
Kwakhona into esebenzayo Brilacidin ukusuka inkampani Amayeza amatsha ayenzelwanga ekuqaleni ngokuchasene neentsholongwane. Endaweni yokuba kuvavanywa unyango lwezifo zesisu kunye nokudumba kwencindi yomlomo. Nangona kunjalo, kulindeleke ukuba ihlasele imvulophu yangaphandle yentsholongwane ye-SARS-CoV-2. Oku kuyavavanywa kwiinkcubeko zeseli.
Inkampani yaseSpain uPharmaMar ifuna ukuvavanya ichiza layo ngeplitidepsin kwisifundo esichasene neCovid-19 emva kokukhuthaza iimvavanyo zaselebhu. Iyeza, elamkelweyo e-Australia nase-mpuma ye-Asiya kunyango lwe-myeloma (uhlobo lomhlaza womongo wethambo), kufuneka inqanda ukuphindaphindeka kwintsholongwane kuba ibhloka iprotein efunekayo ye-EF1A kwiiseli ezichaphazelekayo.
Iqela leziyobisi alilwi ngqo neentsholongwane, kodwa likhuthaza ukuzikhusela komzimba kwiintsholongwane: I-interferons . Zizinto ezahlukeneyo zomthunywa womzimba oveliswa bubunjineli bemfuza. Iingcali zebhayoloji zahlulahlula ezi zinto zomthunywa zaba ngamaqelana aliqela, ekuthi kuwo i-alpha kwaye ii-beta interferon zibalulekile ngokuchasene ne-SARS-CoV-2:
- Iimpawu zeAlfa: Kuluhlu lwezifundo kunye nezigulana zeCovid-19, iziyobisi ezinezithako ezisebenzayo I-interferon alpha-1b , I-interferon alpha-2b (evela kwinkampani yaseCuba iBioCubaFarma kunye nenkampani yaseCuba-Chinese iTshayina i-Changchun Heber Biological Technology), isikhonkwane se-alpha-2a (yenziwe nguRoche), Ikhonkco-Interferon-alpha-2b or Novaferon (yinkampani yamaTshayina uGenova Biotech) esetyenziswa sodwa okanye ukongeza kwamanye amayeza. Ngamanye amaxesha i-alpha interferon yenziwa ngendlela engenakufunyanwa. Onke la machiza avunyiwe ukuba anyangwe usulelo oluthile lwentsholongwane, umzekelo hepatitis B okanye C, kumazwe athile ubuncinci. I-BioCubaFarm ibhengeze ukuba inokuhambisa isixa esikhulu samachiza ayo kwihlabathi liphela.
- Ii-interferon zeBeta: Iziyobisi nge I-interferon beta-1a kwaye I-interferon beta-1b Okwangoku bavavanywa kwizifundo ezichasene neCovid-19. Inkampani yaseJamani iMerck yenza ukuba ichiza layo le-interferon beta-1a lifumaneke kuphando olukhulu liziko le-INSERM eFrance. Zombini izinto ezisebenzayo azinayo imvume kunyango lwe-antiviral kwi-EU, kodwa kuvavanyo lweelebhu i-interferon beta-1a ikwazile ukunqanda ukwanda kweentsholongwane ezinxulumene ne-SARS. Ngohlobo lwe-interferon-beta-1a, inkampani yase-Bhritane USynairgen unayo ifumene imvume yokufunda kwizigulana zeCovid-19.
Pfizer kunjalo ukuvavanya okwangoku iiarhente zentsholongwane elabhoratri eyayenziwe ngaphambili yinkampani yokunyanga ezinye izifo zentsholongwane. Ukuba enye okanye nangaphezulu kuzo zibonakalise kuvavanyo lwaselebhu, iPfizer iya kubabeka kuvavanyo olufanelekileyo lwe-toxicological kwaye baqale ukuvavanya nabantu ekupheleni kuka-2020. MSD ngoku ndiphanda ukuba yeyiphi amachiza antiviral ngokuchasene ne-SARS-CoV-2 inokusebenza. INovartis iphanda ukuba zeziphi iimveliso zayo kwaye zeziphi izinto ezivela kwilayibrari yayo yento yokwenza nonyango lweziyobisi ezinokuthi zilungele unyango lweCovid 19 yezigulana- nokuba zilichiza elichasene neentsholongwane okanye libe ngenye indlela (jonga ngezantsi).
Ukuthintela ii-immunomodulators
Impendulo yomzimba omzimba iyanqweneleka kubantu abasulelekileyo; Akufuneki ukuba zigqithise kangangokuba zibangele umonakalo ongaphezulu kunoncedo emiphungeni.
Ngesi sizathu, iimpendulo zokuzikhusela komzimba kwizigulana ezigula kakhulu ziya kuncitshiswa kwiiprojekthi ezininzi.
ISanofi kunye neRegeneron ke ngoko bavavanya imodareyitha yabo yomzimba isarum kwisifundo kunye nezigulana zeCovid-19 ezichaphazelekayo. Le interleukin-6 antagonist yamkelwe kunyango lwe-rheumatism.
URoche uvavanya i-interleukin-6 antagonist yakhe nguycilizumabkunye nezigulana ze-Covid-19 ezine-pneumonia eqatha. Iyeza sele livunyiwe kunyango lwe-rheumatoid arthritis. Oogqirha baseTshayina nabo bebeyivavanya kwizigulana ezinesifo sehagu iiveki ezimbalwa.
Oogqirha baseTshayina nabo bavavanya i fingolimo i-immunomodulator kunye nezigulana. Yaphuhliswa ngu-Novartis kunyango lwe-multiple sclerosis kwaye yamkelwe kuyo.
ECanada, colchicine ngu kuvavanywa kuvavanyo lweklinikhi ukuya baphathe iimpendulo zomzimba ezigqithileyo, zikhokelwa liZiko lentliziyo laseMontreal. Ichiza evunyiweyo sifo, kwaye kwamanye amazwe kwakhona pericarditis.
Ngengqondo ebanzi unakhoImetaarsenite yesodium (NaAsO 2 ) yenye yeemodyuli zomzimba zokuzikhusela kwizifo kuba kunciphisa ukuveliswa kwezinto ezithile zomthunywa wamajoni omzimba (ii-cytokines), ezinokubangela amandla omzimba. Inkampani yaseMzantsi Korea Komipharm iphuhlise ichiza leentlungu ezinxulumene nethumba (igama leprojekthi PAX-1-001). Ngoku icele izilingo zeklinikhi zokuvavanya ichiza kwizigulana zeCovid-19.
Amayeza ezigulana zemiphunga
Abaphandi baseTshayina bafuna ukuvavanya ichiza laseRoche ngesixhobo esisebenzayo sepirfenidone esele ivunyiwe kwizigulana ezine-idiopathic pulmonary fibrosis. Eli yeza lisebenza ukunqunyulwa kwamathambo emiphunga awonakeleyo.
Inkampani yaseCanada iAlgernon Pharmaceuticals iceba ukuvavanya ichiza layo i-NP-120 ngesixhobo esisebenzayo i-Ifenprodil ukuze ifaneleke. Ukuba i-ifenprodil ngoku ayinalungelo elilodwa lomenzi eJapan naseMzantsi Korea ngokuchasene nezifo zemithambo-luvo. I-Algernon iye yaphuhlisa iyeza ngokuchasene ne-idiopathic pulmonary fibrosis ngale nto isebenzayo ixesha elithile.
Inkampani yaseViennese ye-biotech i-Apeptico ifuna isithako sayo esisebenzayo ISolnatidengokuchasene nokusilela okwangoku kwemiphunga (i-ARSD) yokufaneleka kwezigulana zeCovid-19 ezinomonakalo omkhulu wemiphunga. Kujongwe ukubuyisela ukuqina kweembumba kwithishu yemiphunga.
Inkampani yaseMelika IBioxytran Okwangoku kuphuhliswa ichiza kunye nesithako esisebenzayo I-BXT-25 kwizigulana ezine-ARDS. Kulindeleke ukuba kuphuculwe ukuthathwa kweoksijini kwimiphunga eyonakalisiweyo kwaye kuncede abaguli abanokuthi banikezwe ngokwaneleyo ioksijini ngokusebenzisa imiphunga yokufakelwa. Inkampani ifuna ukuzama iziyobisi kunye neqabane kwizigulana ezigula kakhulu ngeCovid-19.
Amachiza amatsha ngokuchasene neSARS-CoV-2
Inani elikhulayo leeprojekthi lizama nokwenza amayeza amatsha ngokuchasene neCovid-19. Zintathu iintlobo zeeprojekthi:
- Iiprojekthi zentsholongwane zokugonya
- Iiprojekthi ezikhoyo kwinqanaba lokuqala lamachiza antiviral
- Iiprojekthi zophuhliso lwezinto ezifanelekileyo ezifanelekileyo
Nayi eminye imizekelo yeeprojekthi ezivela kwezi ndawo:
Iintsholongwane zokugonya
Enye yeendlela ezindala zamayeza ukulwa nezifo kukufaka inaliti kwizigulana ezineseli yegazi yabantu (okanye yezilwanyana) esele zisindile kwesi sifo. I-diphtheria antiserum ebhalwe ngu-Emil von Behring ukusukela ngo-1891 sele inesiphumo, nokuba bekungekho mntu waziyo malunga neentsholongwane ngexesha. Omnye umzekelo ziisirinji zokugonya ("ugonyo") lwabantu abasenokuba bosulelwe sisifo sokuqina kwemithambo ngenxa yokuba bengagonyelwanga. Kutshanje, amayeza e-Ebola aqukethe i-antibody abonakalise ukuba asebenza kakhulu kwizifundo.
Uninzi lweeprojekthi zophuhliso lwamachiza amatsha ngokuchasene ne-SARS-CoV-2 ke ngoko ijolise kwi-serum yegazi yabo baguli bangaphambili be-Covid 19, ebizwa ngokuba yi "convalescent serum". Ithemba kukuba ezinye ze-antibodies eziqulathiweyo ziya kuba nakho ukunika i-SARS-CoV-2 engakwazi ukuvelisa kwakhona emzimbeni.
Esi sizathu silandelwa yiprojekthi yinkampani yeTakeda: Kwisakhelo se Ithathi-888 Iprojekthi, injongo kukufumana umxube we-antibody kwi-plasma yegazi labantu abaye baphola kwi-Covid-19 (okanye kamva kubantu abagonyelwe i-Covid-19). Umxube onjalo ubizwa i-anti-SARS-CoV-2 polyclonal hyperimmune globulin (H-IG) ; Unyango "ngokugonywa".
Ezinye iinkampani kunye namaqela ophando kwihlabathi nawo alandela olu luvo lusisiseko, kodwa yiya kwelinye inyathelo ngokubhekisele kwibhayoloji: Zikwaqala nge-serum ye-convalescent, kodwa zithathe ezona antibodies zifanelekileyo kwaye emva koko "zikope" ngeendlela zebhayoloji ukuvelisa iziyobisi. Enye yezi projekthi ilandelwa liSweden Karolinska Institute. Enye inkampani, i-AbCellera kunye neLilly, ibhengeze ukuba kwiinyanga nje ezingaphezulu kwe-500 antibodies ezifunyenweyo ziya kusetyenziswa ukwenza ichiza elinokuvavanywa kwizigulana. Kwakhona i-AstraZeneca (UK), iCelltrion (South Korea) kwaye (ngokweengxelo zosasazo) iBoehringer Ingelheim kunye neZiko laseJamani loPhando ngezifo (i-DZIF) basebenzela ukuphuhlisa iyeza ngale ndlela.
Umanyano lwamaziko ophando e-USA luye inyathelo elinye ukuya phambili njengenxalenye yeQonga lokuLungiselela i-DARPA. Ekugqibeleni, iziyobisi zabo akufuneki ziqulathe iikopi zezona zintsholongwane zisebenzayo zisuka kwi-convalescent plasma ngokwayo, kodwa endaweni yoko yimfuzo yayo - ngohlobo lwe-mRNA. Nabani na ojojowe kule mRNA uvelisa izilwa-buhlungu emzimbeni wakhe okwethutyana kwaye uyakhuselwa. Uncedo lwale nkqubo: Kusenokwenzeka ukuba uvelise izixa ezikhulu zamathamo amachiza ngokukhawuleza kunokuba kufuneka uvelise ii-antibodies zebhayoloji. Ukungalunganga: Ukuza kuthi ga ngoku, alikho elinye ichiza elisebenza ngoluhlobo. Iprojekthi ikhokelwa, phakathi kwabanye, nguJames Crowe, iYunivesithi yaseVanderbilt, eTennessee, owafumana iBhaso leNkqubela phambili yeNkcazo kwinkampani yaseJamani iMerck ngo-2019 ngomsebenzi wakhe wokuba nguvulindlela kule nkalo.
Iiprojekthi ezininzi zamachiza amatsha ziyahluka "kwindlela yokuthambisa". Yiyo loo nto iVir Biotechnology ngaphambili Iintsholongwane ezivela kwi-serum yegazi yezigulana Ichongwe ngoku ifunyenwe kubuchwephetshe beSARS bonyaka ka-2003. Inkampani ngoku iyahlola kwiziko lase-US i-NIH kunye ne-NIAID ingaba bayakwazi na ukunqanda ukuphindaphindeka kwe-SARS-CoV-2. IVir Biotechnology iyasebenzisana nenkampani yaseMelika iBiogen kunye nenkampani yaseTshayina iWuXi Biologics kwimveliso ye-biotechnological "yeekopi" zezi ntsholongwane.
Isazinzulu esivela kwiDyunivesithi yase-Utrecht (eNetherlands) saye savavanya izilwa-buhlungu ezivela kwi-serum yegazi ye-SARS convalescents ukususela ngo-2003. Bafumana isibulala-ntsholongwane esinokuthintela ukwanda kwe-SARS-CoV-2 kwinkcubeko. Kuya kufuneka ngoku kuvavanywe ngakumbi. URegeneron unjalo Ukuqhuba iprojekthi efanayo: Inkampani ivavanya ichiza ngee-monoclonal ntibodies UMSEBENZI 3048 kwaye UMSEBENZI 3051 Kwisigaba endifunda ngaso namavolontiya. Ezi ntsholongwane zenzelwe ukunyanga i-MERS coronavirus, enxulumene ne-SARS-CoV-2. Iiprojekthi ezikhoyo kwinqanaba lokuqala lamachiza antiviral Iqela lophando kwiYunivesithi yaseLübeck lilandela enye indlela
Sele kuyiminyaka kuphuhliswa oko kubizwa ngokuba yi-alpha-ketoamides njengee-antiviral agents ngokuchasene ne-corona kunye ne-enteroviruses (ezijongene nokubola komlomo phakathi kwezinye izinto). Kuvavanyo lwaselebhu, izinto ezintsha zovavanyo zithintela ukuphindaphindwa kwezi ntsholongwane. Enye yazo, ebizwa ngokuba yi "13b", yenzelwe ukulwa neentsholongwane zekorona. Ngoku iya kuvavanywa kwinkcubeko yeseli nakwizilwanyana kwaye, kwimeko yeziphumo ezilungileyo, kuvavanywa kwizifundo nabantu kunye nenkampani eyenza amayeza.
Iiprojekthi ezintsha zophuhliso lweziyobisi
Inani leenkampani ezinkulu ezixuba amayeza ziye zadibana ukwenza amayeza amatsha onyango (anje ngezigonyo kunye noxilongo) ngokuchasene neCovid-19. Kwinyathelo lokuqala, baya kwenza ezabo ingqokelela yemolekyuli ezikhoyo, apho idatha ethile kukhuseleko kunye nendlela yokusebenza sele ikhona. Ezi ziya kuvavanywa liziko le- "Covid-19 Therapeutics Accelerator", nelamiselwa yiGates Foundation, Wellcome neMastercard. Iimolekyuli ezichazwe njengezithembisayo, iimvavanyo zezilwanyana kufuneka ziqale kwinyanga ezimbini. Iqela leenkampani libandakanya iBD, bioMérieux, Boehringer Ingelheim, Bristol-Myers Squibb, Eisai, Eli Lilly, Giliyadi, GSK, Janssen (Johnson & Johnson), MSD, Merck, Novartis, Pfizer kunye neSanofi.
Iinkampani zilandela isicwangciso esahlukileyo iVir Pharmaceuticals kunye neAlnylam Pharmaceuticals. Ubhengeze ukuba uza kuphuhlisa okubizwa ngokuba zii-siRNA agents ezithintela intsholongwane ngokubangela ezinye zofuzo ziyeke ukusebenza. Le ndlela ibizwa ngokuba kukuvala inzala.
Kukhawuleza kangakanani?
Zonke iziyobisi kufuneka zihlolwe ukuba zikulungele na ukunyangwa kwabantu abane-Covid-19. Oku kusebenza nakwamachiza asele evunyiwe kwezinye izigulana okanye kuvavanywe kakhulu. Abasemagunyeni abalawulayo kufuneka babe nakho ukusebenzisa iziphumo ukuvavanya ichiza ngalinye ngokusebenza, ukunyamezeleka kunye nomgangatho wobuchwephesha. Nangona kunjalo, abasemagunyeni abalawulayo banike umqondiso wokuba baya kubeka phambili zombini iinkqubo zokuvunywa kwezilingo zeklinikhi kunye neenkqubo zokuvunywa kwamachiza avavanywe ngempumelelo. Iinkampani ziya kuba nakho ukungenisa izicelo zokuvunywa "isahluko ngesahluko", esiya kuthi sikhawulezise ukuphononongwa ngabasemagunyeni.
Nangona kunjalo, amava kunye nezixhobo ezinokuzisa iinkampani esele ziphuhlisa kwaye zithengisa amayeza iminyaka ziya kuba yimfuneko kwindlela ekhawulezayo yokufumana amayeza afanelekileyo kukhathalelo lwezigulana. Umzekelo, inkampani iPfizer inikezele ngegalelo lamava ayo abanzi kwizifundo, iinkqubo zokuvunywa kunye nophuhliso lwenkqubo yokuvelisa kunye namandla ayo emveliso ngokusebenzisana neenkampani ezincinci eziphuhlisa iziyobisi ze-corona. Inkampani iyakwenza neendlela zelabhoratri eziyenzileyo kuphando lwayo lwe-corona olufumanekayo kuye wonke umntu "kwimithombo evulekileyo".
