Uvavanyo oluyimpumelelo lweklinikhi lokuNyanga i-Cerebral Stroke eAcute usebenzisa i-Umbilical Cord Blood

Uphononongo lweSigaba I lwenziwe kwizigulane ezineminyaka engama-45-80 ubudala eziye zagcina i-acute ischemic stroke. Igazi le-Umbilical cord lifunyenwe kuluhlu lwegazi lwe-StemCyte lukawonkewonke olusekelwe kuhlobo lwegazi lwe-ABO/Rh, umdlalo we-Human Leukocyte Antigen (HLA) we> 4/6, kunye ne-cell dose ye-cell mononuclear (MNC) isibalo se-0.5-5 x 107 iiseli / kg. Ukongeza, iidosi ezine (4) 100 mL ze-mannitol zafakwa emithanjeni imizuzu engama-30 kulandela utyalo-gazi lwe-umbilical cord kwaye rhoqo kwiiyure ezi-4 emva koko.

Iziphumo eziphambili yayilinani lezigulane eziphuhlise i-graft versus host disease (GVHD) phakathi kweentsuku ezili-100 emva kotofelo-gazi. Iziphumo zeSekondari zitshintshile kwiiNational Institutes of Health Stroke Scale (NIHSS), index Barthel, kunye neBerg Balance Scale scores. Kwimeko enye, isigulane esineminyaka engama-46 ubudala esinembali yoxinzelelo lwegazi kunye ne-hemodialysis kwisigaba sokugqibela sesifo se-renal saphathwa nge-allogeneically usebenzisa i-hUCB kunye ne-ABO / Rh efanayo, umdlalo we-6 / 6 we-HLA, kunye ne-MNC count ye-2.63 x 108 iiseli/kg. Isigulane asizange sibonise iziganeko ezibi kakhulu okanye i-GVHD ngexesha leenyanga ze-12. Amanqaku akhe e-NIHSS ancipha ukusuka kwi-9 ukuya kwi-1; i-Berg Balance Scale score yanda ukusuka kwi-0 ukuya kwi-48, kwaye i-index index ye-Barthel yanda ukusuka kwi-0 ukuya kwi-90. Olu pho nonongo lwangaphambili lubonise ukuba isigulane esidala esine-hemiplegia ngenxa ye-stroke ye-ischemic yachacha ngokupheleleyo kwiinyanga ze-12 emva kokufumana unyango lwe-UCB ye-allogeneic.

"Siyavuya kakhulu ngesiphumo seklinikhi esiyimpumelelo kwisifundo seSigaba sokuQala seStemCyte," utshilo uMongameli weStemCyte kunye noSihlalo uJonas Wang, PhD. "Nge-stroke eyingozi eyesibini neyesithathu ebangela ukufa kunye nokukhubazeka, ngokulandelanayo, kwihlabathi jikelele, esi siphumo sibalaseleyo njengoko bekungalindelekanga." Malunga nama-30% -35% abantu abahlaselwa sistrowuku bafa kwaye phantse i-75% yamaxhoba agcina ukukhubazeka okusisigxina. Unyango lwangoku kwinqanaba elibukhali libandakanya ukusetyenziswa kwe-thrombolytic, i-anticoagulant, kunye ne-antiplatelet agents. Nangona kunjalo, ukusetyenziswa kwee-agent ezinjalo kwandisa iziganeko ze-hemorrhage nge-15% -20%.

Iiseli zegazi zentambo ziyanda kwiiseli ze-neural, kwaye zifunyenwe zisebenza kunyango lwezifo ezininzi ze-neurodeergenerative. Kwi-stroke ye-cerebral, i-injection ye-intravenous ye-UCB kunye ne-MNCs inokubuyisela amandla okusebenza kunye nokubonelela ngemiphumo ye-neuroprotective njengoko kuboniswe ngokunciphisa ukubonakaliswa kwamanqaku avuthayo afana ne-TNF-alpha, IL-1β kunye ne-IL-2.