Uphononongo olutsha: Isinye kwisithathu sabasetyhini bafumana i-Misdiagnosis yeKlinikhi yeVaginitis

Kwiphepha, ukuSebenza kweVaginal Panel Assay xa kuthelekiswa ne-Clinical Diagnosis ye-Vaginitis-ebika iziphumo ezivela kulingo lwezonyango lwe-BD - izizathu ezintathu ze-vaginitis (i-bacterial vaginosis [BV], i-vulvovaginal candidiasis [VVC] okanye i-Trichomonas vaginalis [TV ]) zaphononongwa ukuthelekisa uvavanyo lweekliniki kunye neziphumo ezivela kuvavanyo lwemolekyuli. Uphononongo lufumene ukuba xa kuthelekiswa novavanyo lwe-molecular, ukuxilongwa kweklinikhi kulahlekile i-45.3 yeepesenti zamatyala afanelekileyo (i-180 ye-397) kwaye ichonge ngokungalunganga i-12.3 yeepesenti zamatyala angalunganga njengezinto ezintle (123 ye-879).

Uphononongo luphinde lwakhethwa ukuba lufakwe kwi-Obstetrics & Gynecology Journal Club, ekhetha izifundo ezimbini ukuya kwezintathu ngomba ngamnye ukunika abafundi bezonyango ithuba lokuphonononga amaphepha abalulekileyo kwaye bancede bakhe isiseko sobungqina obusekelwe kubungqina.

Phakathi kwe-6 yezigidi kunye ne-10 yezigidi zokutyelelwa kwezempilo ngabasetyhini base-US zihambelana neempawu ze-vaginitis.1,2 Nangona i-vaginitis yimeko eqhelekileyo, ukuxilongwa kwezizathu zayo eziqhelekileyo3,4 (BV, VVC, okanye TV) kubasetyhini bokuzala. iminyaka ayibekwanga emgangathweni.

"I-misdiagnosis ithetha iziphakamiso ezingafanelekanga zonyango - mhlawumbi ukuxhatshazwa okanye ukunyanzeliswa," watsho umlobi-mbhali wesifundo uMolly Broache, unxibelelwano lwesayensi yezonyango kwi-Integrated Diagnostic Solutions kwi-BD. “Ibhinqa lisenokucelwa ukuba libuyele kwagqirha ngokungeyomfuneko, okanye lisenokunganyangeki ngenxa yokuba lisebenzisa amayeza okubulala iintsholongwane akuwafuni ngokwenene.”

Uphononongo luthelekisa ukuxilongwa koogqirha be-vaginitis kwiziphumo zepaneli yepaneli ye-vaginal assay eyenziwa kwi-BD MAX™ System, i-FDA-market egunyazisiweyo yovavanyo lwemolekyuli esebenzisa i-nucleic acid amplification ukufumanisa izizathu ze-microbial ze-BV, i-VVC, kunye ne-TV. Uphononongo lubandakanya abathathi-nxaxheba abangama-489 abaneempawu. Abathathi-nxaxheba bafumana ukuxilongwa kweklinikhi kwaye babe ne-swab ye-vaginal assay eqokelelwe ngexesha lokutyelela kwabo. Iiswabs zathunyelwa kwiziko lovavanyo elahlukileyo kwaye kamva zathelekiswa noxilongo lukagqirha.

"Ngenene senza abafazi ukuba bangabikho kwezonyango xa singasebenzisi izixhobo ezingcono kakhulu esinazo zokuxilonga unobangela okanye izizathu zeempawu ezibaqhubele ukuba bafune unyango," watsho umbhali-mbhali uBarbara Van Der Pol, Ph.D. ., MPH kunye noNjingalwazi wezoNyango kunye neMpilo yoLuntu. “Usulelo oluninzi lubangelwa zizinto ezininzi eziphilayo ukuze sicinge ukuba singazichonga ngokuchanekileyo ngaphandle kovavanyo olukumgangatho ophezulu. Idatha ekweli phepha iqinisekisa ukuba sityala abasetyhini ezona ndlela zibalaseleyo ezikhoyo kwaye uqwalaselo lwezonyango alwanelanga. ”

I-BD MAX ™ iVaginal Panel Assay inokunceda ukujongana nemida yokuxilongwa kweklinikhi kwaye inokunceda ukuphucula ukuchaneka koxilongo. Olu vavanyo oluzenzekelayo lunexesha elifutshane lokuguqula (malunga neeyure ezintathu ukuqhuba phakathi kweesampuli ezimbini kunye ne-24 ngaxeshanye), ngoko ke iziphumo zosuku olufanayo zinokwenzeka ukuba ugqirha unesixhobo esifumanekayo kwisayithi. Uvavanyo oluzenzekelayo lwe-assay lwenzelwe ukunciphisa ukuguquguquka kunye nokuzithoba, ngaloo ndlela inceda ukwandisa ukuchaneka koxilongo.

“Xa owasetyhini efunyaniswa kakubi nangayiphi na indlela- exelelwa ukuba akanayo i-vaginitis kodwa eneneni uyayenza okanye uxelelwe ukuba une-vaginitis kodwa akosuleleki- kudala ubunzima kunye nomngcipheko,” utshilo uBroache. "Abafazi bafanelwe ngcono."