Ulwazi olutsha ngoHlaselo loMhlaza ngokuLungiswa koKhuseleko lwe-Immune

I-Myeloid Therapeutics, Inc. namhlanje ibonise idatha entsha yokuqhawula kade kwiNtlanganiso yoNyaka ye-American Association for Cancer Research (AACR), eyayibanjelwe eNew Orleans, LA, ngo-Aprili 8-13, ngo-2022.             

Idatha eboniswe kwi-AACR 2022 ibonisa ukuba i-Myeloid iyile kwaye yaphuhlisa amaqonga eenoveli zonyango, i-ATAK ™ CAR receptors kunye ne-vivo mRNA programming, ukujolisa kunye nokwenza ukuba iiseli ze-myeloid zisebenze ukuhlasela umhlaza ngokuhlelwa kwakhona komzimba. Iiseli ze-Myeloid ziyi-orchestrator ephambili yokusabela komzimba kwaye ziqokelelana ngokwendalo ngaphakathi kwamathumba aqinileyo, kwezinye iimeko zimele ukuya kuthi ga kumashumi asixhenxe anesihlanu eepesenti zobunzima bethumba. Uhlengahlengiso lwe-Myeloid ye-mRNA yekhompatimenti ye-myeloid yandisa impembelelo yezi seli ngaphakathi kwimifuniselo ye-vivo.

Iklasi yenoveli ye-Myeloid yee-CAR, ezaziwa ngokuba zii-ATAK™ Receptors, zidibanisa ukuqondwa kwethumba kunye neendawo ezininzi zokubonisa i-innate-immune signing. Izazinzulu ze-Myeloid ziye zavavanya imidibaniso emininzi engaphononongwanga yemiqondiso ye-innate-immune kwaye yafumanisa iindlela ezifanelekileyo zemiqondiso emininzi. Ukudityaniswa kwezibophelelo zokuqondwa komhlaza kunye nale noveli ye-intracellular signaling domains ivumela iiseli ze-myeloid ukuba ziphinde zicwangciswe ngokutsha kunye nendibaniselwano ebikade ingaphononongwa yemiqondiso yokuzikhusela komzimba, ekhokelela ekubulaweni kwethumba kunye neempendulo ezibanzi zenkqubo yokuchasana nethumba.

Inoveli kaMyeloid kwiqonga lobunjineli be-vivo ijolise ngokukodwa kwaye ivule iiseli ze-myeloid ukuze zenze ukhuseleko olubanzi lwe-anti-tumor. Ngale ndlela, iMyeloid ibonisa ukuba ukuhanjiswa kwe-lipid-nanoparticles (LNPs) egquma i-mRNA ikhokelela ekuthatheni okukhethiweyo kunye nokubonakaliswa kweeseli ze-myeloid kwi-vivo, ekhokelela ekubulaweni kwethumba elinamandla kwiimodeli ezininzi ezibandayo ezibandayo. Ezi datha zibonisa ukuba kunokwenzeka kwitekhnoloji yeMyeloid yokucwangcisa iiseli ngqo kwi-vivo.

“Kwindibano yalo nyaka ye-AACR, sonwabile ukubonisa inkqubela phambili ebonakalayo kuwo onke amaqonga ethu abonisa amandla eeseli ze-myeloid zokucwangcisa iimpendulo ezibanzi zokhuselo lomzimba ngokusebenzisa inkqubo ye-vivo mRNA kunye nesizukulwana esilandelayo see-ATAK™ CARs,” utshilo uBruce McCreedy, Ph. D., iGosa eliyiNtloko lezeNzululwazi laseMyeloid. "Ezi datha zixhasa izicwangciso zethu zokuqalisa ulingo lwezonyango lokuvavanya ukhuseleko kunye nomsebenzi wabaviwa abaninzi bemveliso yeziyobisi kulo nyaka uzayo, sandise umbhobho wethu wekliniki okhoyo."