Ngokwengxelo yemihla ngemihla yase-Italiya, u-Il Corriere della Sera, kukho izinto ezikhoyo kwizithambiso, amayeza, kunye nokutya okunokubangela isitofu sokugonya se-COVID kwabanye abantu ngenxa yokuvezwa kwangaphambili. Into ebangela ukuba abantu bangaphenduli emva kokuba befumene iPfizer Isitofu se-covid inokufunyanwa. Oku kunokuba yinxalenye ye "polyethylene glycol", ekwabizwa ngokuba yi-PEG.
Ikhompawundi eqhelekileyo kwizithambiso
Nangona iziphathamandla zempilo zisaphanda, njengoko inkampani eyenza amayeza uqobo isenza, siyazi ukuba i-PEG inokudityaniswa ngendlela enqabileyo kunye neempendulo ezichaseneyo njengoko kuqinisekisiwe nguPeter Marks, uMlawuli weZiko loVavanyo lweeMveliso noPhando, i-US Food and Drug Administration (FDA) iimveliso zebhayoloji.
Ezo zinto zingahambelaniyo kunokuba yinto eqhelekileyo kunaleyo inqabileyo edla ngokwenzeka. Ikhompawundi ifumaneka kwiishampu, izinto zokuthambisa kunye nezinye iimveliso ezininzi. Abanye abantu banokuba semngciphekweni ngakumbi kuba banamanqanaba aphezulu ee-antibodies kwi-PEG. Kuzo zombini ezi zitofu, iPfizer-BioNTech kunye neModerna, i-PEG yinxalenye yemvulophu enamafutha ejikeleze i-RNA yomthunywa, esona sithako siphambili sokugonya.
Nje ukuba i-mRNA ingene kwiiseli, iyabafundisa ukuba benze iprotein efana ne-spike protein efumaneka kumphezulu we-coronavirus. Oku kubangela impendulo ethile yomzimba yomeleze ukhuseleko lomzimba xa ifunyenwe kwintsholongwane yokwenyani. Imvulophu enamafutha equlathe i-PEG iyanceda ukuqinisekisa ukuba i-mRNA inqumle inwebu yeseli. I-PEG ayikaze isetyenziswe kwisitofu esivunyiweyo ngaphambili, kodwa iyafumaneka kumachiza amaninzi. Olu phononongo kwezi veki zizayo luyakwenziwa kubantu abanamanqanaba aphezulu ee-anti-PEG okanye abanamava eempendulo ezimbi kumachiza okanye kwizitofu ngaphambili.
Amatyala negazi lakho
Ukuphendula kwe-Anaphylactic kunokwenzeka nangaluphi na ugonyo kodwa kuhlala kunqabile kakhulu- malunga nesinye kwisigidi esinye sedosi. Ukusukela nge-1 kaDisemba ngo-1, nangona kunjalo, i-United States ibizibonile iimeko ze-19 ze-anaphylaxis phakathi kwabantu abangama-2020 abafumene isitofu sokugonya kunye ne-United Kingdom benamatyala amabini kwizifundo ze-Phase 6 ezikhokelele ekwamukelweni kwezitofu abantu ababekhutshelwa ngaphandle. Ngembali yokwaliwa zizinto kumachiza okuthintela, i-subgroup yabantu, ke ngoko, inokuba ibimelwe kakubi.
Inani elonyukayo leemveliso zebhayopharmaceutical zibandakanya ii-PEGs. Ngokophando olwenziwe ngo-2016 kwiDyunivesithi yaseNorth Carolina, eChapel Hill, iipesenti ezingama-72 zabantu banamajoni omzimba omncinci kwii-PEGs, mhlawumbi ngenxa yokuvezwa kwezithambiso kunye namayeza. Phantse iipesenti ezisi-7 banenqanaba elinokuphakama ngokwaneleyo ukuba babanikezele kwiimpendulo ze-anaphylactic.
Iingcebiso
Okwangoku akukabikho kuqiniseka kodwa kuphela okucingelwayo: ezinye izazinzulu ziyaqaphela ukuba inani le-PEG kwizitofu ze-mRNA lingaphantsi kunelo liqulethwe luninzi lweziyobisi. Okwangoku, ezinye iindlela ze-PEG ziyafundwa, kodwa umkhankaso wokugonya awuyeki, nangenxa yokuba izibonelelo zingaphezulu komngcipheko kwaye bonke abo bachaphazelekayo kukungabikho komzimba baye bafumana.
Izikhokelo ezivela Amaziko oLawulo lweZifo kunye noThintelo (CDC) e-USA ungacebisi ukuba unganiki isitofu sokugonya sePfizer okanye iModerna kuye nabani na onembali yokungalungelani kakhulu nelinye iyeza lokuthintela. Akukho sizathu sokuba abantu abanembali yokuphendula kancinci okanye okunzima kokutya, izilwanyana zasekhaya, amayeza omlomo, okanye i-allergen yokusingqongileyo akufuneki bafumane iyeza lokugonya iCDC ithi. Kwaye abantu abanokuba semngciphekweni omkhulu wokuphendula nge-anaphylactic kufuneka bahlale kwindawo yokugonya kangangemizuzu engama-30 emva kwenaliti (hayi i-canonical kuphela eyi-15).
I-COVID, “eyahlukileyo yesiNgesi,” iseLombardy: amatyala amabini okuqala achongiwe
Umahluko wecoronavirus uchongiwe nguSan Matteo wasePavia. Into ebizwa ngokuba "sisiNgesi" eyahlukileyo ye-Sars-CoV-2 coronavirus, intsholongwane ejongene ne-COVID, nayo ichongiwe eLombardy. Iindaba zibonelelwa yiPoliclinico San Matteo ePavia.
Amatyala amabini okuqala ngabemi base-Itali aba-2 abafike eMalpensa kwiintsuku nje ezidlulileyo- kanye nge-23 ne-24 kaDisemba. Esi siganeko sichaza isibhedlele, "azimelanga omnye nomnye kwaye azihambelani kwaphela kuqhambuko."
Iisampulu ezivavanywe zilungile kwi-molekyuli swab zithunyelwe yi-ATS Insubria kwi-IRCCS Policlinico San Matteo Foundation ePavia apho iqela likaNjingalwazi Fausto Baldanti lenze ulandelelwano.
Oko kubizwa ngokuba "kukwahluka kwesiNgesi" kuchongiwe kwiintsuku zakutshanje kwimimandla eyahlukeneyo yase-Italiya (eLazio, Abruzzo, Campania, Veneto, Marche, nase Puglia), kwaye kusenokwenzeka ukuba sele igcwele nakwezinye iindawo intsimi.
Ngokophando olukhoyo ngoku kwaye iingcali zenziwe nodliwanondlebe neCorriere della Sera, lo mahluko unamandla okusasazeka anokuba phezulu (ukuya kuthi ga kwi-70%). Akukho bungqina bokuba iyingozi okanye iyabulala, kwaye ayikwazi ukuxhathisa izitofu ezivunyiweyo okanye ezamkelweyo ngokuchasene ne-COVID.
Akucaci ukuba okwahluka kwavela eGreat Britain, nangona kunjalo, ichongiwe apho kwaye yabalasela kwindawo esemazantsi mpuma elizwe. Phakathi koqikelelo lwemvelaphi yalo, iZiko laseYurophu lokuJongwa kwezifo eziSulelayo lacacisa ukuba kungenzeka ukuba lavela kwisigulana esine-immuneosupist, esasulelayo, sasinosulelo ixesha elide ngaphambi kokuchacha, sithanda ukuqokelelwa kweenguqu ezincinci.
Ngenxa yokusasazeka kwayo, urhulumente wase-Bhritane usungule amanyathelo aqatha okutshixeka impela-veki ephelileyo. I-European Union nayo ithathe amanyathelo okunciphisa ukuhamba phakathi kwe-Great Britain kunye namazwe e-EU ukuya kubuncinci.
Amatyala ama-2 axelwe yi-Policlinico San Matteo achongwa emva kokuqalisa kokusebenza kwale mithetho.
Nge-26 kaDisemba, i-2020, iJapan yathatha isigqibo sokuvala imida yayo kubantu bamanye amazwe kude kube nge-31 kaJanuwari, ngo-2021, emva kokuchongwa "kwesiNgesi" esitsha kwabanye abakhweli ababefika bevela eGreat Britain.
# ulwakhiwo
