Ubhaliso luqukumbela uVavanyo olutsha kuKhohlokhohlo oluNgapheliyo

I-Trevi Therapeutics, Inc. yinkampani ye-biopharmaceutical yenqanaba leklinikhi ephuhlisa unyango lophando i-Haduvio™ (nalbuphine ER). Namhlanje, uTrevi ubhengeze ukuba ugqibe ukubhalisa kwangethuba kwiSigaba sesi-2 sokuKhohlela kunye ne-NALbuphine (CANAL) kulingo lonyango lokhohlokhohlo olungapheliyo kwizigulana ze-idiopathic pulmonary fibrosis (IPF) kulandela iziphumo ebezibhengezwe ngaphambili ezibaluke ngokwezibalo kuhlalutyo lwethutyana (N=26). ). Ukuphela kokuphumelela okuphambili kubonise ukunciphisa kwe-77.3% kwi-frequency yokukhwehlela emini ukusuka kwisiseko kunye nokusetyenziswa kwe-Haduvio xa kuthelekiswa nokunciphisa i-25.7% kunye ne-placebo, ebonisa ukuncipha kwe-52% ye-placebo kwi-geometric ithetha ipesenti yokutshintsha kwixesha lokukhwehlela emini (p <0.0001).

Ngenxa yokuba ulingo lufumene ukubaluleka kwamanani kuhlalutyo lwexeshana, iisayithi zaziswe ukuba zinokubhalisa izifundo ezifanelekileyo esele zisekuhlolweni kodwa akukho mfuneko yokongezwa kwabasebenzi. Malunga nezifundo ezingama-40 zizonke ezibhalisiweyo kuphononongo. Inkampani iyaqhubeka nokulindela ukunika ingxelo ngokusebenza kunye nokhuseleko kwiseti epheleleyo yezifundo kwikota yesithathu ka-2022.

I-IPF sisifo esimandundu, sokuphela kobomi apho ukhohlokhohlo luye lolona phawu lubalulekileyo. Kuqikelelwa ukuba yi-130,000 yezigulane ze-IPF e-US kunye nezigulana ezingaphezu kwesigidi esi-1 ezazihlala e-US, apho ukuya kuthi ga kwi-85% yezi zigulana zifumana ukhohlokhohlo olungapheliyo. Alukho unyango oluvunyiweyo lokunyanga ukhohlokhohlo olungapheliyo kwi-IPF, kwaye ukhohlokhohlo luhlala luphikisana nonyango lwe-antitussive. Izigulana ezinokhohlokhohlo olungapheliyo kwi-IPF zinokukhohlela ukuya kuthi ga kumaxesha angama-520 ngosuku, nto leyo ekhokelela ekwandeni kweemvakalelo zokuxhalaba njengoko ibangela ukuphefumla. Ukukhohlela okanye iziqendu zikhokelela ekudinweni okukhulu, ukulamba komoya, ukuphelelwa umoya kweoksijini kwaye ezinye izigulana zikwanengxaki yokhohlokhohlo lokungaphumeleli komchamo. Impembelelo yezentlalo yokhohlokhohlo olungapheliyo kwi-IPF iphinda idibanise amandla okuzilolonga, ukunciphisa umgama wokuhamba kunye nesidingo sokusebenzisa ioksijini eyongezelelweyo. Ukhohlokhohlo olungapheliyo kwi-IPF isenokuba luphawu lweklinikhi lwakwangoko lomsebenzi wesifo, chonga abaguli abasemngciphekweni omkhulu wokuqhubela phambili, baqikelele ixesha lokufa okanye uqhaqho-fakelo lwemiphunga, kwaye lunokuba negalelo ekuphuculweni kokusebenza kweendlela zeprofibrotic kunye nezifo eziya ziba mandundu kwi-IPF.