Okubalulekileyo, ingxelo yangoku, epapashwe kwi-Intanethi nge-13 kaJanuwari kwi-Alzheimer's & Dementia: Ijenali yoMbutho we-Alzheimer, yaqhutywa ngaphezulu kweenyanga ezimbini kwangoko kubhubhane (ngoMatshi-ngoMeyi 2020). Nakuphi na umiselo lokuba ngaba abaguli abane-COVID-19 basemngciphekweni owonyukayo wesifo i-Alzheimer, okanye endaweni yoko balulame ekuhambeni kwexesha, kufuneka balinde iziphumo zezifundo zexesha elide.
Ikhokelwe ngabaphandi kwi-NYU Grossman School of Medicine, uphononongo olutsha lufumene amanqanaba aphezulu asixhenxe omonakalo wobuchopho (i-neurodegeneration) kwizigulana ze-COVID-19 ezineempawu ze-neurological kunezo zingenazo, kunye namanqanaba aphezulu kwizigulana ezibhubhele esibhedlele kunokuba kwabo bakhululwe bagoduswe.
Uhlalutyo lwesibini lufumanise ukuba iseti engaphantsi yamanqaku omonakalo kwizigulana ezilaliswe esibhedlele nge-COVID-19, kwixeshana elifutshane zaziphezulu kakhulu kunezigulana ezafunyaniswa zinesifo i-Alzheimer's, kwaye kwimeko enye ngaphezulu kokuphindwe kabini ukuphakama.
"Iziphumo zethu zibonisa ukuba abaguli abalaliswe esibhedlele ngenxa ye-COVID-19, kwaye ngakumbi abo baneempawu ze-neurological ngexesha losulelo lwabo olunzima, banokuba namanqanaba okwenzakala kwengqondo aphakamileyo, okanye aphezulu kunalawo abonwa kwizigulana ezinesifo i-Alzheimer's," uthi umbhali okhokelayo uJennifer A. Frontera, MD, uprofesa kwiSebe le-Neurology kwi-NYU Langone Health.
Ulwakhiwo/iinkcukacha
Uphononongo lwangoku luchonge abaguli abangama-251 ukuba, nangona beneminyaka engama-71 ngokwe-avareji, babengenarekhodi okanye iimpawu zokuncipha kwengqondo okanye isifo sengqondo esixhalabisayo ngaphambi kokuba balaliswe esibhedlele ngenxa ye-COVID-19. Ezi zigulana ke zahlulwa zangamaqela aneempawu ze-neurological kunye nangaphandle kweempawu zabo ze-neurological ngexesha losulelo lwabo oluqatha lwe-COVID-19, xa izigulana ziye zachacha kwaye zakhutshwa, okanye zasweleka.
Iqela lophando nalo, apho kunokwenzeka, lithelekise amanqanaba abamakishi kwiqela le-COVID-19 kwizigulana kwi-NYU Alzheimer's Disease Research Centre (ADRC) Clinical Core cohort, uphononongo oluqhubekayo, lwexesha elide kwi-NYU Langone Health. Akukho nasinye kwezi zigulana zilawulayo zili-161 (ngama-54 ngokwengqondo eqhelekileyo, engama-54 enokukhubazeka okuphakathi kwengqondo, kunye nama-53 afunyaniswa enesifo sika-Alzheimer) ane-COVID-19. Ukulimala kwengqondo kwalinganiswa kusetyenziswa iteknoloji ye-molecule ye-molecule (SIMOA), ekwazi ukulandelela amanqanaba egazi emizuzu ye-neurodegeneration markers kwii-piccograms (i-trillionth ye-gram) nge-milliliter yegazi (pg / ml), apho ubuchwepheshe obudala bungenako.
Amanqaku amathathu okufunda - i-ubiquitin carboxy-terminal hydrolase L1 (UCHL1), i-tau iyonke, i-ptau181 - imilinganiselo eyaziwayo yokufa okanye ukukhubaza i-neurons, iiseli ezenza i-nerve pathways ithwale imiyalezo. Amanqanaba e-neurofilament light chain (NFL) ayanda ngomonakalo kwii-axons, izandiso ze-neurons. Iprotein ye-glial fibrillary acidic (GFAP) ngumlinganiselo womonakalo kwiiseli zeglial, ezixhasa i-neurons. I-Amyloid Beta 40 kunye ne-42 ziiprotheyini ziyaziwa ukuba zakha kwizigulane ze-Alzheimer's disease. Iziphumo zophononongo oludlulileyo ziphikisa ukuba i-tau epheleleyo kunye ne-phosphorylated-tau-181 (p-tau) nazo ziyimilinganiselo ethile ye-Alzheimer's disease, kodwa indima yabo kwesi sifo ihlala ingumcimbi wengxoxo.
Iimpawu zegazi kwiqela lezigulana ze-COVID zaye zalinganiswa kwiserum yegazi (inxalenye yolwelo yegazi eyenziwe ukuba ihlwili), ngelixa ezo zikuphononongo lwe-Alzheimer zaye zalinganiswa ngeplasma (iqhezu legazi lolwelo elisalayo xa ihlwili lithintelwa). Ngenxa yezizathu zobugcisa, umahluko wawuthetha ukuba amanqanaba e-NFL, GFAP, kunye ne-UCHL1 inokuthelekiswa phakathi kweqela le-COVID-19 kunye nezigulana kuphononongo lwe-Alzheimer, kodwa iyonke i-tau, i-ptau181, i-Amyloid beta 40, kunye ne-amyloid beta 42 inokuthelekiswa kuphela ngaphakathi. iqela lezigulane ze-COVID-19 (iimpawu ze-neuro okanye hayi; ukufa okanye ukukhutshwa).
Ngaphaya koko, owona monakalo uphambili wemithambo yemithambo-luvo kwizigulana ze-COVID-19 yayiyityhefu ye-metabolic encephalopathy, okanye i-TME, eneempawu zokusuka kwisiphithiphithi ukuya kwi-coma, kwaye yabangelwa ngexesha losulelo oluqatha lwetyhefu eyenziwa njengoko amajoni omzimba esabela ngokugqithisileyo (sepsis), izintso ziyasilela (uremia) , kunye nokuhanjiswa kweoksijini kuphazamisekile (hypoxia). Ngokukodwa, ipesenti yokunyuka kwepesenti kumanqanaba asixhenxe abamakishi bezigulane ezibhedlele nge-TME xa kuthelekiswa nalabo abangenazo iimpawu ze-neurological (umzobo we-2 kwisifundo) yipesenti ze-60.5. Kwabamakishi abafanayo kwiqela le-COVID-19, ukonyuka kwepesenti yomndilili xa kuthelekiswa abo bakhutshwe ngempumelelo ekhaya esibhedlele kwabo babhubhela esibhedlele yi-124 pesenti.
Iseti yesibini yeziphumo zavela ekuthelekiseni amanqanaba e-NFL, i-GFAP kunye ne-UCHL1 kwiserum yezigulana ze-COVID-19 ngokuchasene namanqanaba ophawu olufanayo kwiplasma yezigulana ze-Alzheimer ezingeyo-COVID (umzobo 3). I-NFL yayingaphezulu kwexesha elifutshane le-179 yeepesenti ephezulu (i-73.2 xa ithelekiswa ne-26.2 pg/ml) kwizigulana ze-COVID-19 kunezigulana ze-Alzheimer. I-GFAP yayingama-65 epesenti ephezulu (443.5 xa ithelekiswa ne-275.1 pg/ml) kwizigulana ze-COVID-19 kunezigulana ze-Alzheimer, ngelixa i-UCHL1 yayiyi-13 yeepesenti ephezulu (43 xa ithelekiswa ne-38.1 pg/ml).
"Ukwenzakala kwengqondo okubuhlungu, okukwanxulunyaniswa nokunyuka kwezi mpawu, akuthethi ukuba isigulane siya kuba ne-Alzheimer's okanye i-dementia ehlobene nayo kamva, kodwa iyakwandisa ingozi," kusho umbhali ophezulu uThomas M. Wisniewski, MD. UGerald J. kunye noDorothy R. Friedman uNjingalwazi kwiSebe le-Neurology kunye nomlawuli weZiko le-Cognitive Neurology kwi-NYU Langone. "Enoba olu hlobo lobudlelwane lukhona kwabo basinde kakhulu kwi-COVID-19 ngumbuzo ekufuneka siwuphendule ngokukhawuleza ngokubeka iliso kwezi zigulana."
Kunye noGqr. Frontera kunye neWisniewski, ababhali be-NYU Langone Health baquka umbhali wokuqala uAllal Boutajangout, Arjun Masurkarm, Yulin Ge, Alok Vedvyas, Ludovic Debure, Andre Moreira, Ariane Lewis, Joshua Huang, Sujata Thawani, Laura Balcer, noSteven Galetta. Kwakhona umbhali yayinguRebecca Betensky kwiSikolo seYunivesithi yaseNew York yeMpilo yoLuntu yeHlabathi. Olu phononongo luxhaswe ngenkxaso-mali evela kwiziko leSizwe lokuguga kwi-COVID-19 esongezo solawulo 3P30AG066512-01.
