Ngokutsho kwe-ADx Health, "Ngokumangalisayo, abantu babelana nge-99% yekhowudi yofuzo efanayo. I-1% ekhethekileyo ibandakanya utshintsho kwiziseko ezithile ze-nucleotide, okubangela utshintsho kwimizila ethile, kwaye kwezinye iimeko, utshintsho kwimingcipheko yezifo ezithile, "kuquka umngcipheko we-Alzheimer's disease.
Ngoku yamkelwe ngokubanzi ukuba isifo se-Alzheimer sibangelwa zombini ukuguqulwa (okufana nesondlo, ukuzivocavoca, ukulala) kunye nokungaguqukiyo (i-genetics, ubudala, isondo) imingcipheko yengozi. Ngelixa i-APOE yeyona nto iyaziwa kakhulu kwi-genetic factor ehambelana nobungozi besifo se-Alzheimer, uvavanyo lwe-GenoRisk polygenic luvavanya i-29 genes ngaphezu kwe-APOE.
Nangona kunjalo, uninzi lwezifundo zophando ziye zasebenzisa kuphela ingozi yemfuza ye-APOE ekuhloleni izifundo, ishiya izikhewu ezibalulekileyo ekuqondeni umfanekiso opheleleyo wokuqikelelwa komngcipheko we-AD, yingakho i-ADx Health yavelisa indlela entsha yokuvavanya i-Alzheimer's kunye novavanyo lweGenoRisk.
Idatha yophononongo lwe-GenoRisk ibonisa ukuba kunokubakho uluhlu olubanzi lweengozi ngaphakathi kwe-APOE genotype. Kwezinye iimeko, abantu abanomngcipheko osezantsi ngokwahluka kwe-APOE banokuba sengozini ephezulu yemfuza kunomntu onomngcipheko ophezulu owahluka we-APOE ngenxa yokubandakanywa kweminyaka kunye nohlengahlengiso lwesini.
"Ngokuqonda ngcono indlela izakhi zofuzo ezininzi ezisebenzisana ngayo ekuchazeni ingozi ye-AD, olu hlobo lovavanyo lwe-polygenic lunokubonelela ngolwazi olungakumbi kulawulo lwe-Alzheimer yomntu ngamnye, kubandakanywa nendlela izigulane eziphathwa ngayo, iziphelo zezilingo zeklinikhi, kunye nemilinganiselo yokunciphisa ingozi", watsho uRyan Fortna. , MD, omnye wababhali besifundo.
