UKhetho olutsha lokuHlola kwiZigulana ezikuMngcipheko oMkhulu wePancreatic Cancer

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IAvatar kaLinda Hohnholz
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Iziko lezoNyango leYunivesithi yaseHackensack lisungule inkqubo entsha yokuhlola abantu abasemngciphekweni omkhulu wokuba nomhlaza wepancreatic.             

Uvavanyo lwe-IMMray® PanCan-d luvavanyo lwegazi lokuqala kwimarike olunikezelwe ekubhaqweni kwangethuba kwe-familia okanye i-pancreatic ductal adenocarcinoma (PDAC).

Izigulana ezifanelekileyo ziya kufumana zombini uvavanyo lokucinga kunye novavanyo lwenoveli lwe-biomarker olulinganisa impendulo yamajoni omzimba kwisifo sepancreatic egazini.

"Umhlaza wangaphambili ufunyenwe, lingcono ithuba lonyango oluyimpumelelo," utshilo uRosario Ligresti, MD, intloko yeGastroenterology kwiZiko lezoNyango leYunivesithi yaseHackensack, iZiko leSizwe lePancreas Foundation of Excellence ukususela ngo-2013, apho eli nyathelo litsha linikezelwa njengenxalenye ye inkqubo yesibhedlele yokubeka iliso kumngcipheko ophezulu womhlaza wepancreatic.

Ngelishwa, uphando lubonisa kuphela malunga nekota yabantu abafanelekele ukubeka iliso kwingozi enkulu ngokwenene bathatha ithuba, kodwa uGqr.

"Umhlaza we-Pancreatic, enye yezona zibulala kakhulu zomhlaza, kunzima ukufumanisa kwangaphambili, kwinqanaba xa ukuhlinzwa kokuhlinzwa, kuphela unyango lonyango olunokwenzeka," uDkt. Ligresti uyachaza. "Olu vavanyo lutsha lubonakaliswe ukuba lubhaqa umhlaza we-pancreatic kwinqanaba lokuqala kwizigulana ezisengozini enkulu, ngenjongo yokuwubamba ngaphambi kokuba ube nethuba lokusasazeka kwezinye izicubu."

Ngubani ojongwa njengosemngciphekweni omkhulu? 

Umhlaza wePancreatic unokuqhutywa kusapho kwaye/okanye unokudityaniswa neemeko zemfuza ezonyusa umngcipheko wezinye iintlobo zomhlaza. Oku kubizwa ngokuba ngumhlaza wepancreatic kwaye kubandakanya iimeko kubantakwenu, abazali kunye nootatomkhulu kwizizukulwana zangoku zosapho lwakho. Wena kunye nosapho lwakho unokuba sengozini enkulu ukuba izalamane ezi-2 okanye ngaphezulu zokuqala okanye ubuncinane amalungu amathathu entsapho afunyanwe enomhlaza we-pancreatic.

Ngowuphi umgangatho wangoku wokhathalelo lovavanyo?

Okwangoku, uvavanyo lwe-pancreas lomhlaza lwenziwa kusetyenziswa nokuba yi-MRI okanye i-endoscopic ultrasound (EUS). Olu luvavanyo olukhethekileyo olubandakanya i-endoscope kunye ne-high-frequency ultrasound ukwenza umfanekiso we-pancreas ngokuchanekileyo. Iimvavanyo zenziwa ngonyaka kwaye zombini zinezinto ezilungileyo nezingalunganga. I-MRI inokuba nzima, ibize kwaye idle ixesha. I-EUS ibandakanya i-endoscopy encinci kwaye ifuna ukuzila ukutya kunye ne-sedation. IZiko lezoNyango leYunivesithi yaseHackensack ibisenza uvavanyo lwe-pancreas ngale ndlela iminyaka emininzi. Ngaphambili ngoku, akukho vavanyo lwegazi olukhethekileyo okanye oluchanekileyo olukhoyo ngokurhweba ukuvumela ukuhlolwa komhlaza wepancreas.

Ngubani ofanelekela olu vavanyo lutsha lomhlaza wepancreas?

Ukujongwa komhlaza wepancreas kubaluleke kakhulu kula maqela alandelayo asemngciphekweni omkhulu. Nasiphi na isigulana esidala kuneminyaka eyi-18 kunye:

• Utshintsho lweBRCA

• Icystic fibrosis

• IFamilial Adenomatous Polyposis (FAP)

• IFamily Atypical Multiple Mole Melanoma (FAMMM)

• I-Hereditary Nonpolyposis Colorectal Cancer (HNPCC) okanye iLynch Syndrome

• I-Hereditary Pancreatitis

• Utshintsho lwePALB2

• I-Peutz-Jeghers Syndrome

• Imbali yosapho yomhlaza wepancreas kwizizalwane ezimbini zenqanaba lokuqala

Yintoni iprothokholi yokuhlola?

Izigulane ziya kuba nothethwano olubanzi kunye noDkt Ligresti. Emva koko baya kuba novavanyo lwe-IMMray PanCan-d kunye ne-MRI okanye i-EUS eyenziwa. Emva kokuba zonke iziphumo zikhoyo, baya kudibana noDkt Ligresti ukuba baphonononge kunye nesicwangciso sokuqhubeka kokubeka iliso. Oku kwenziwa rhoqo ngonyaka.

Kutheni kubalulekile ukufunyaniswa kwangoko komhlaza we-pancreatic? Iimpawu zikhula kuphela ngesifo senqanaba kade, ngoko uninzi lomhlaza wepancreatic lufunyaniswa kumanqanaba kade xa unyango lungasebenzi kakuhle.

Ngubani osemngciphekweni wokuba nomhlaza wepancreatic? Ukuchonga izigulane ezisemngciphekweni wokuphuhlisa isifo ngenxa yokuguqulwa kwemfuza eyaziwayo okanye imbali yentsapho yomhlaza we-pancreatic kunokubaluleka ekufumaneni kwangethuba. Amaqela asemngciphekweni omkhulu amele umlinganiselo omkhulu wazo zonke iimeko zomhlaza wepancreas.

Lusebenza njani olu vavanyo lutsha? I-IMMray PanCan-d ihlalutya i-9 biomarkers kwi-serum ukuze ibone i-pancreatic ductal adenocarcinoma (PDAC), uhlobo oluqhelekileyo lomhlaza we-pancreatic. I-Biomarkers echaphazelekayo kwiinkqubo ezininzi zeselula ezibandakanya imetabolism, ukuvuvukala kunye nomonakalo wezicubu / ukulungiswa, kunye ne-CA19-9, zibandakanyiwe kwi-assay. Impendulo yesampulu kwi-biomarker nganye iyalinganiswa kwaye emva koko idityaniswe kusetyenziswa i-algorithm ukumisela isiphumo sovavanyo lwe "High-Risk Signature Present", "Negative for High-Risk Signature", okanye "Borderline".

Uvavanyo lokuSebenza: Kupapasho lwamva nje oluphononongwe ngontanga nguBrand et al epapashwe kwi-Clinical and Translational Gastroenterology, uvavanyo lwe-IMMray PanCan-d lubonise uvakalelo lwe-92% kunye ne-99% ethile ekufumaneni i-pancreatic ductal adenocarcinoma (PDAC) usebenzisa i-serum. Uvavanyo lwe-IMMray PanCan-d lukwazile ukubona iSigaba I & II PDAC nge-89% yobuntununtunu kunye ne-99% ethile.

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IAvatar kaLinda Hohnholz

Linda Hohnholz

Umhleli oyintloko we eTurboNews esekwe kwi-eTN HQ.

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