Uphononongo olutsha ngesiphumo sokuLwa utyatyazo lwe-Cashew Stem Bark Extract

I-Anacardium occidentale (Ao), umthi we-cashew oqhelekileyo, sisityalo esele siqatshelwe kwiinkqubo zamayeza esintu ngenxa yamandla aso onyango. Ngokomzekelo, iindawo ezahlukahlukeneyo zalo mthi, amagqabi, amaxolo, iimbewu zembewu, nentlaka, ziyaziwa ukuba zinempembelelo yokulwa norhudo. Nangona kunjalo, iindlela ezichanekileyo zokusebenza zihlala ziyimfihlakalo.            

UDkt. Kayode E. Adewole ovela kwiYunivesithi yeSayensi yezoNyango, eNigeria, kunye noogxa bazama ukuphazamisa iindlela ngokuphanda umsebenzi wokulwa nesifo sohudo kwi-stem bark extract yemithi ye-cashew. Uqwalaselo lwabo oluthembisayo lusanda kupapashwa kwiJournal of Pharmaceutical Analysis.

Ibangelwa zizinto ezahlukeneyo ezifana nokunganyamezeli kokutya, usulelo lwentsholongwane, iziyobisi, kunye nokuphazamiseka kwamathumbu, urhudo luyinkxalabo enkulu yempilo yoluntu, kwaye lubangela ukubhubha kwabantwana okubalulekileyo. Ngokuqhelekileyo, esi sifo sibonisa ukunyuka kwe-gut motility. Ukuphonononga indlela yokulwa nesifo sohudo ye-cashew stem bark extract, abaphandi bagxininise kwiindlela zeselula kunye nabadlali abaphambili beemolekyuli ababandakanyekayo kwi-innormal gut motility kwaye bayila uluhlu lwezilingo ezisekwe elebhu.

UGqr Adewole uyachaza, "Isifo sohudo siphumela ekunyusweni kwemisipha egudileyo yamathumbu, elawulwa ngokuqhelekileyo ngeendlela ezintathu ze-neurophysiological, i-dopaminergic, i-cholinergic, kunye ne-serotonergic. Ke ngoko, indlela yethu yovavanyo ibikukuvuselela ngokuzenzekela ukuhamba kwesisu kwindlela nganye kwezi kwaye sibone ukuba yeyiphi kwezi ethintelwe sisicatshulwa sexolo le-cashew stem. Uvavanyo lwethu lwahlulahlulwe lwaba ngamacandelo amabini, kwi-vivo, eyenziwa kwiimpuku eziphilayo, kunye ne-in vitro, eyenziwa kwiiseli zamathumbu.

Iqela lilawula i-gastrointestinal motility-inducing drugs, oko kukuthi i-metoclopramide (i-dopamine receptor antagonist), i-carbachol (i-acetylcholine receptor agonist), kunye ne-serotonin (evuselela i-serotonergic receptors), ukwahlula amaqela eempuku. Amanye amaqela amathathu afumana amayeza afanayo kodwa anyangwa ngexolo lecashew stem.

Baye bafumanisa ukuba iqhezu le-ethyl acetate elilungisiweyo lesicatshulwa (elibhalwe AoEF) kakhulu lithintele indlela ye-cholinergic yokukhupha isisu kunye nokuhamba kwesisu kodwa ayinayo impembelelo kwezinye iindlela ezimbini, inika ingqiqo engcono kwindlela yokusebenza yesicatshulwa.

Njengenxalenye yovavanyo lwe-in vitro, abaphandi baye bakhetha imichilo emathunjini eehagu zeGuinea kwaye bafumanisa ukuba kwindawo ephezulu, i-AoEF ngokufanelekileyo nangokuyibuyisela umva le micu. Oku kwabonwa nakwimicu eyayiphathwa ngaphambili nge-AoEF emva koko yaphathwa ngeeathom zeprokinetic ezifana ne-histamine, i-serotonin, kunye ne-acetylcholine.

Ngaphezulu, kusetyenziswa igesi chromatography-mass spectroscopy, iqela lichonge amacandelo angama-24 akhoyo kwi-AoEF. Izifundo ezisekelwe kwi-Bioinformatics zibonise ukuba phakathi kwezi zixhobo, i-octadecanoic acid 2- (2-hydroxylethoxy) i-ethyl ester yayinobudlelwane obuphezulu obubophezelayo kwi-muscarinic acetylcholine receptor M3 (CHRM3). Oku kwavumela iqela ukuba lidibanise ubungqina obuvela kuzo zonke iimvavanyo ezahlukeneyo kwaye lifike kwindlela enokwenzeka yokwenza isicatshulwa.

Ukudibanisa amandla olwazi lwendabuko kunye nesayensi yanamhlanje, uDkt Adewole kunye neqela lakhe banethemba lokuba ukufumanisa kwabo kuya kukhuthaza ukuqulunqwa kwamayeza amatsha aphantsi kweendleko zokunyanga nokulawula isifo sohudo.