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Izigulana zoMhlaza wamabele waKwangoko zinokuluphepha uNyango lweKhemo

Kuphononongo, abafazi be-postmenopausal abane-1 ukuya kwi-3 i-nodes emihle kunye ne-Recurrence Score® iziphumo ze-0 ukuya kwi-25 zibonisa ukuba akukho nzuzo kwi-chemotherapy emva kweminyaka emihlanu yokulandelelana, oku kuthetha ukuba banokuphepha imiphumo emibi yonyango.

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I-Exact Sciences Corp. namhlanje ibhengeze ukuba idatha evela kwi-Rx ye-Positive Node, i-Endocrine Responsive Breast Cancer, okanye i-RxPONDER, ilingo lipapashwe kwi-New England Journal of Medicine.i Uphononongo, olukhokelwa yi-SWOG Cancer Research Network ezimeleyo kwaye ixhaswe ngu I-National Cancer Institute (NCI), ichaze ngempumelelo inzuzo ye-chemotherapy kwinqanaba lokuqala, izigulane zomhlaza wesifuba ze-node-positive kunye ne-Oncotype DX Breast Recurrence Score® iziphumo ze-0 ukuya kwi-25. Iziphumo zokuqala ezivela kwi-RxPONDER zichazwe kwi-2020 ye-San Antonio Breast Cancer. I-Symposium (SABCS). Okufunyenweyo ngoku kuqinisekisiwe kolu papasho luphononongwe ngoontanga.

Okubalulekileyo, akukho nzuzo ye-chemotherapy yabonwa kungakhathaliseki inani leendawo ezichaphazelekayo, ibakala le-tumor okanye ubungakanani. Kwabasetyhini be-premenopausal abane-1 ukuya kwi-3 i-node ezintle, inzuzo ye-chemotherapy ephawulekayo yabonwa.

Malunga nesinye kwisithathu sezigulana ezifunyaniswe zine-hormone receptor (HR)-positive, i-HER2-negative ekuqaleni umhlaza wamabele zinethumba elithe lanwenwela kwii-lymph nodes. Uninzi lwezi zigulana ngoku zifumana ichemotherapyii nangona malunga ne-85% yazo ineziphumo zokuPhinda kokuPhinda kuka-0 ukuya kuma-25.

Ngokusekwe kwiziphumo ze-RxPONDER, iNational Comprehensive Cancer Network® (NCCN®)v ihlaziye izikhokelo zayo zomhlaza wamabele kwaye yaqaphela uvavanyo lwe-Oncotype DX Breast Recurrence Score njengovavanyo kuphela olunokuthi lusetyenziswe ukuqikelela inzuzo yechemotherapy ekuqaleni kwebele. izigulane zomhlaza kunye ne-1 ukuya kwi-3 ye-axillary lymph nodes e-positive, kuquka i-micrometastases.vi Uvavanyo lwe-Oncotype DX ngoku kuphela kovavanyo oluchazwe "njengolukhethwayo" olunobungqina obuphezulu bobungqina be-node-negative kunye ne-postmenopausal node-positive (1 ukuya kwi-3 i-positive nodes ) izigulane. Ukongeza, i-NCCN incoma ukuqwalasela uvavanyo lokuvavanya i-prognosis kwizigulane ze-premenopausal node-positive ezingabaviwa be-chemotherapy.

Olona vavanyo lukhulu lwezonyango kwi-node-positive, i-HR-positive, i-HER2-negative ekuqaleni komhlaza wamabele, i-RxPONDER ibhalise ngaphezu kwama-5,000 abasetyhini kunye neendawo ezintathu ezilungileyo. Uphononongo olulindelekileyo, olungenamkhethe lweSigaba sesi-III lwaqhutywa kwiindawo ezingama-632 kumazwe alithoba - eUnited States, eCanada, eMexico, eKholombiya, e-Ireland, eFransi, eSpain, eMzantsi Korea naseSaudi Arabia. Abasetyhini abanesiphumo sokuPhinda kwakhona kwesiphumo se-0 ukuya kwi-25 benziwe ngokungakhethiyo kunyango ngonyango lwehomoni yodwa okanye ichemotherapy elandelwa lunyango lwehomoni. Izigulane ezihleliweyo zahlulwe ngokusekwe kwisiphumo seNqaku lokuPhinda, imeko ye-menopausal kunye nohlobo lotyando lwe-lymph node. Uhlalutyo olongezelelweyo kunye nokulandelela isigulane esongezelelweyo kucwangciswe ngabaphandi be-SWOG.

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U-Linda Hohnholz, umhleli we-eTN

U-Linda Hohnholz ubhale kwaye wahlela amanqaku ukusukela oko waqalisa ukusebenza. Usebenzise olu thando lwangaphakathi kwiindawo ezinje ngeHawaii Pacific University, iYunivesithi yaseChaminade, iZiko lokuFumanisa abantwana laseHawaii, kwaye ngoku iTravelNewsGroup.

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